Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoprolifer-ati...

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Bibliographic Details
Published in:Nature (London) 1992-03, Vol.356 (6367), p.314-317
Main Authors: Watanabe-Fukunaga, Rie, Brannan, Camilynn I, Copeland, Neal G, Jenkins, Nancy A, Nagata, Shigekazu
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigens, Surface - genetics
Autoimmunity (experimental aspects and models)
Base Sequence
Biological and medical sciences
Blotting, Southern
Cell Death
DNA Mutational Analysis
fas Receptor
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene Expression
Gene Rearrangement
Genes
Genetics
Humanities and Social Sciences
Lymphoproliferative Disorders - genetics
Mice
Mice, Mutant Strains
Molecular Sequence Data
multidisciplinary
Mutation
Oligodeoxyribonucleotides - chemistry
Polymerase Chain Reaction
Proteins
RNA, Messenger - genetics
Science
Science (multidisciplinary)
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Summary:Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoprolifer-ation ( Ipr ) mutation have defects in the Fas antigen gene. The Ipr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus.
ISSN:0028-0836
1476-4687
DOI:10.1038/356314a0