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Nuclear Reprogramming in Cells
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusio...
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| Published in: | Science (American Association for the Advancement of Science) 2008-12, Vol.322 (5909), p.1811-1815 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c630t-f67f829a220ad0d814a8836b691666e72f57b26ea9e34222d28a1749659660c33 |
| container_end_page | 1815 |
| container_issue | 5909 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 322 |
| creator | Gurdon, J.B Melton, D.A |
| description | Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these methods it becomes possible to derive one kind of specialized cell (such as a brain cell) from another, more accessible, tissue (such as skin) in the same individual. This has potential applications for cell replacement without the immunosuppression treatments that are required when cells are transferred between genetically different individuals. This article provides some background to this field, a discussion of mechanisms and efficiency, and comments on prospects for future nuclear reprogramming research. |
| doi_str_mv | 10.1126/science.1160810 |
| format | article |
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Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these methods it becomes possible to derive one kind of specialized cell (such as a brain cell) from another, more accessible, tissue (such as skin) in the same individual. This has potential applications for cell replacement without the immunosuppression treatments that are required when cells are transferred between genetically different individuals. This article provides some background to this field, a discussion of mechanisms and efficiency, and comments on prospects for future nuclear reprogramming research.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1160810</identifier><identifier>PMID: 19095934</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Anura ; Biological and medical sciences ; Cell Dedifferentiation ; Cell Differentiation ; Cell Fusion ; Cell Lineage ; Cell lines ; Cell nucleus ; Cellular biology ; Cellular differentiation ; Cellular Reprogramming ; Cloning, Organism ; DNA - metabolism ; DNA-Binding Proteins - metabolism ; Embryonic cells ; Embryonic Stem Cells - cytology ; Embryonic Stem Cells - physiology ; Female ; Fundamental and applied biological sciences. 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Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these methods it becomes possible to derive one kind of specialized cell (such as a brain cell) from another, more accessible, tissue (such as skin) in the same individual. This has potential applications for cell replacement without the immunosuppression treatments that are required when cells are transferred between genetically different individuals. 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Psychology</subject><subject>Gene Expression</subject><subject>Genetic engineering</subject><subject>Humans</subject><subject>Induced pluripotent stem cells</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Molecular biology</subject><subject>Neurons</subject><subject>Nuclear Transfer Techniques</subject><subject>Oocytes - cytology</subject><subject>Pluripotent stem cells</subject><subject>Pluripotent Stem Cells - cytology</subject><subject>Pluripotent Stem Cells - physiology</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>Review</subject><subject>Somatic cells</subject><subject>Stem cells</subject><subject>Totipotent stem cells</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkc1vEzEQxS0EoqFw5kSJkCinpTPj9dg-VhFQpAokoGfLcbzRRvtR7Oyh_z0OWVGJQ3vyWO83T89-QrxG-IhIfJFDG4cQy4XBIDwRCwSrKksgn4oFgOTKgFYn4kXOO4CiWflcnKD9O9ULcfZtCl30afkj3qZxm3zft8N22Q7LVey6_FI8a3yX46v5PBU3nz_9Wl1V19-_fF1dXleBJeyrhnVjyHoi8BvYGKy9MZLXbJGZo6ZG6TVx9DbKmog2ZDzq2rKyzBCkPBUfjr4lxO8p5r3r2xxKAj_EccpO11Ii10oV8vxBkq1FWawfBSXXpvjxoyABKUv6EPLdf-BunNJQ_sURSmW11qZAF0copDHnFBt3m9repzuH4A6dubkzN3dWNs5m22ndx809P5dUgPcz4HPwXZP8ENr8jyMEBIVUuDdHbpf3Y7rXAbUGPjz07VFv_Oj8NhWPm59FlYBKo0Ur_wDF163v</recordid><startdate>20081219</startdate><enddate>20081219</enddate><creator>Gurdon, J.B</creator><creator>Melton, D.A</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20081219</creationdate><title>Nuclear Reprogramming in Cells</title><author>Gurdon, J.B ; Melton, D.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-f67f829a220ad0d814a8836b691666e72f57b26ea9e34222d28a1749659660c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Anura</topic><topic>Biological and medical sciences</topic><topic>Cell Dedifferentiation</topic><topic>Cell Differentiation</topic><topic>Cell Fusion</topic><topic>Cell Lineage</topic><topic>Cell lines</topic><topic>Cell nucleus</topic><topic>Cellular biology</topic><topic>Cellular differentiation</topic><topic>Cellular Reprogramming</topic><topic>Cloning, Organism</topic><topic>DNA - metabolism</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Embryonic cells</topic><topic>Embryonic Stem Cells - cytology</topic><topic>Embryonic Stem Cells - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2008-12, Vol.322 (5909), p.1811-1815 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Alma/SFX Local Collection |
| subjects | Animals Anura Biological and medical sciences Cell Dedifferentiation Cell Differentiation Cell Fusion Cell Lineage Cell lines Cell nucleus Cellular biology Cellular differentiation Cellular Reprogramming Cloning, Organism DNA - metabolism DNA-Binding Proteins - metabolism Embryonic cells Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology Female Fundamental and applied biological sciences. Psychology Gene Expression Genetic engineering Humans Induced pluripotent stem cells Male Molecular and cellular biology Molecular biology Neurons Nuclear Transfer Techniques Oocytes - cytology Pluripotent stem cells Pluripotent Stem Cells - cytology Pluripotent Stem Cells - physiology Regulatory Sequences, Nucleic Acid Review Somatic cells Stem cells Totipotent stem cells Transcription Factors - genetics Transcription Factors - metabolism |
| title | Nuclear Reprogramming in Cells |
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