Neutralizing and Hemagglutination-Inhibiting Antibodies to Rubella Virus as Indicators of Protective Immunity in Vaccinees and Naturally Immune Individuals

In general, hemagglutination-inhibiting (HAl) and neutralizing (NT) antibodies to rubella virus tend to parallel one another, and the presence of either antibody has been interpreted as reflecting protective immunity. It has recently been shown that persons who have HAl antibody but lack NT antibody...

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Bibliographic Details
Published in:The Journal of infectious diseases 1978-12, Vol.138 (6), p.877-883
Main Authors: Schluederberg, Ann, Horstmann, Dorothy M., Andiman, Warren A., Randolph, Martin F.
Format: Article
Language:English
Subjects:
Adult
Animals
Antibodies
Antibodies, Viral - isolation & purification
Cells, Cultured
Child
Children
Haplorhini
Hemagglutination Inhibition Tests
Humans
Immunity
Immunity, Innate
Infections
Military Medicine
Neutralization Tests
Rabbits
Reinfection
Rubella
Rubella - immunology
Rubella Vaccine - immunology
Rubella virus
Rubella virus - growth & development
Rubella virus - immunology
Scientific Articles
Time Factors
Vaccination
Vero cells
Viruses
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Summary:In general, hemagglutination-inhibiting (HAl) and neutralizing (NT) antibodies to rubella virus tend to parallel one another, and the presence of either antibody has been interpreted as reflecting protective immunity. It has recently been shown that persons who have HAl antibody but lack NT antibody may be subject to reinfection. In the present study these two antibodies were compared with regard to their appearance and persistence in vaccinees and in those who have experienced natural infection. NT antibody appeared more slowly following immunization with HPV77DE5 or Cendehill vaccines than after natural infection or immunization with RA 27/3 vaccine. As with natural infection, initial NT antibody responses to RA 27/3 vaccine were of higher titer and persisted at higher levels for three years than was the case with either of the other vaccines.NT testing procedures were found to differ in sensitivity, depending on several factors including the cells in which the virus was grown.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/138.6.877