Therapeutic effects of glucose infusion on monochloroacetic acid exposure in rats

The effects of glucose infusion on monochloroacetate (MCA) exposure were examined in male rats with a view toward effective clinical treatment for MCA intoxication. Rats were injected with 80 mg/kg sodium monochloroacetate (SMCA) (single lethal dose) and then infused with saline (control group) or 5...

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Bibliographic Details
Published in:Toxicology and industrial health 2002-09, Vol.18 (8), p.389-395
Main Authors: Shimizu, Hiroyasu, Dote, Tomotaro, Usuda, Kan, Toshina, Yumi, Kato, Junko, Sakai, Akiko, Furuya, Eisuke, Kono, Koichi
Format: Article
Language:English
Subjects:
Acetates - toxicity
Acidosis
Acidosis, Lactic - prevention & control
Acids
Animals
Blood Glucose - analysis
Glucose
Glucose - administration & dosage
Hypoglycemia
Hypoglycemia - prevention & control
Infusions, Intravenous
Intravenous therapy
Lactic Acid - blood
Male
Poisoning
Public health
Rats
Rats, Sprague-Dawley
Survival Rate
Toxicology
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Summary:The effects of glucose infusion on monochloroacetate (MCA) exposure were examined in male rats with a view toward effective clinical treatment for MCA intoxication. Rats were injected with 80 mg/kg sodium monochloroacetate (SMCA) (single lethal dose) and then infused with saline (control group) or 5% or 10% glucose solution at 2 mL/hour for ten hours. No animal in the control group survived the total 14-day follow-up period. The survival rate in 5% glucose group was 57% at ten hours; it decreased to 14% at 14 days. The survival rate in 10% glucose group was 79% at ten hours, and all rats that survived the first ten hours also survived the 14 days. Kaplan -Meier analysis showed the survival rate in 10% glucose group to be improved upon in both the 5% glucose group and the control group. Blood glucose and lactate levels were measured every hour during infusion. Blood glucose levels decreased in the control group but remained in the glucose-infused groups. Although the blood lactate level increased in each group, there was an excellent inverse linear relation between blood glucose levels and blood lactate levels. Thus, continuous parenteral infusion of glucose solution at an early stage after exposure may be an effective clinical therapy for the prevention of hypoglycaemia and metabolic lactic acidosis caused by MCA.
ISSN:0748-2337
1477-0393
DOI:10.1191/0748233702th163oa