Effects of a specially pulsed electric field on an animal model of wound healing

The possible beneficial effects of a specially pulsed electric field (PEF) on wound healing were investigated in this study. We made a pair of triangular, full-thickness, dorsal incisions in the skin of 32 healthy male mice (one control group and three exposure groups). The treatment groups were kep...

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Bibliographic Details
Published in:Lasers in medical science 2009-09, Vol.24 (5), p.735-740
Main Authors: Cinar, Kenan, Comlekci, Selcuk, Senol, Nurgul
Format: Article
Language:English
Subjects:
Animals
Capillaries - growth & development
Collagen - biosynthesis
Dentistry
Electric fields
Electric Stimulation Therapy - methods
Exudates and Transudates - physiology
Inflammation - pathology
Lasers
Male
Medicine
Medicine & Public Health
Mice
Models, Animal
Optical Devices
Optics
Original Article
Photonics
Quantum Optics
Rodents
Skin - blood supply
Skin - injuries
Skin - pathology
Skin - physiopathology
Wound healing
Wound Healing - physiology
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Summary:The possible beneficial effects of a specially pulsed electric field (PEF) on wound healing were investigated in this study. We made a pair of triangular, full-thickness, dorsal incisions in the skin of 32 healthy male mice (one control group and three exposure groups). The treatment groups were kept between parallel plates in a partially insulated exposed environment. Group I was exposed to an electric field intensity of 10 kV/m, group II was exposed to 1.9 kV/m, and group III was exposed to 0.9 kV/m. PEFs were applied to the subjects for 20–22 h and 8 consecutive days. We determined the differences in wound recovery between the groups based on the following parameters: collagen fiber density, inflammatory infiltration density, capillary proliferation, and existence of exudates. We found that a 0.9 kV/m–1.9 kV/m chopped direct current (DC) electric field with a 30 µs repetition time favorably affected collagen synthesis and wound recovery. Despite the intensity of 0.9–1.9 kV/m, PEF accelerated healing, but 10 kV/m decelerated this recovery process.
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-008-0631-6