Iron-Catalyzed Regioselective Hydroaryloxylation of CC Triple Bonds: An Efficient Synthesis of 2H-1-Benzopyran Derivatives

An efficient, regioselective, iron‐catalyzed intramolecular hydroaryloxylation of 2‐propargylphenols or naphthols is reported. The reactions proceed through an endo‐dig cyclization to afford benzopyran or naphthopyran derivatives in good to high yields using iron(III) chloride as the catalyst with t...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2009-11, Vol.351 (16), p.2599-2604
Main Authors: Xu, Xiaobing, Liu, Jun, Liang, Linfeng, Li, Hongfeng, Li, Yanzhong
Format: Article
Language:English
Subjects:
benzopyrans
hydroaryloxylation
iron catalysis
naphthopyrans
regioselective cyclization
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Summary:An efficient, regioselective, iron‐catalyzed intramolecular hydroaryloxylation of 2‐propargylphenols or naphthols is reported. The reactions proceed through an endo‐dig cyclization to afford benzopyran or naphthopyran derivatives in good to high yields using iron(III) chloride as the catalyst with the assistance of aniline in dimethylformamide (DMF).
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200900483