Imipramine and EEG sleep in children with depressive symptoms

Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a...

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Bibliographic Details
Published in:Psychopharmacology 1979-01, Vol.60 (2), p.117-123
Main Authors: Kupfer, D J, Coble, P, Kane, J, Petti, T, Conners, C K
Format: Article
Language:English
Subjects:
Adolescent
Child
Depression - drug therapy
Depression - physiopathology
Electroencephalography
Female
Humans
Imipramine - pharmacology
Imipramine - therapeutic use
Male
Sleep - drug effects
Sleep, REM - drug effects
Time Factors
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Summary:Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a pilot study employing these techniques was undertaken in a population of hospitalized children. The EEG sleep of 12 children with significant depressive symptomatology was first examined after a two-week drug-free period and again approximately three weeks later when an optimum dose of imipramine had been maintained for at least 7 -- 10 days. Changes in sleep continuity, as reflected in increased wakefulness and a decreased sleep efficiency, as well as an increase in Stage 2 and a decrease in Stage 4 sleep, were observed throughout the entire sample. REM suppression was also noted, but tended to be most pronounced in those children who improved on imipramine.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00432281