Age-Related Lesions in the Cerebrum in Middle-Aged Female Cynomolgus Monkeys

Alzheimer’s disease (AD) in humans is a progressive neurogenic disease that can be linked with such characteristic pathological findings in the cerebrum as senile plaques (SPs), neurofibrillary tangles (NFTs), cerebral amyloid angiopathy (CAA), and neuronal loss. In the present study, the authors in...

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Bibliographic Details
Published in:Toxicologic pathology 2010-02, Vol.38 (2), p.303-311
Main Authors: Kodama, Rinya, Yang, Xiuying, Saski, Yuji, Iwashige, Shuichiro, Tanigawa, Yohei, Yoshikawa, Tsuyoshi, Nagaoka, Takaharu, Kamimura, Yasuhiro, Maeda, Hiroshi
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Age Factors
Aging - pathology
Animals
Astrocytes - cytology
Biological and medical sciences
Cell Count
Cerebral Amyloid Angiopathy - pathology
Cerebrum - pathology
Cynomolgus
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Hippocampus - cytology
Macaca fascicularis
Medical sciences
Microglia - cytology
Neurofibrillary Tangles - pathology
Neurology
Neurons - cytology
Organic mental disorders. Neuropsychology
Plaque, Amyloid - pathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Toxicology
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Summary:Alzheimer’s disease (AD) in humans is a progressive neurogenic disease that can be linked with such characteristic pathological findings in the cerebrum as senile plaques (SPs), neurofibrillary tangles (NFTs), cerebral amyloid angiopathy (CAA), and neuronal loss. In the present study, the authors investigated the age-related morphological changes in 12 middle-aged and 12 young cynomolgus monkeys. Low numbers of neurons and astrocytes in the hippocampal region in cynomolgus monkeys accompanied ageing, and there was a high number of microglial cells; however, no clearly neurotoxic abnormalities due to β-amyloid were noted before the age of 20 years. The onset of SPs and CAA in the cerebrum in cynomolgus monkeys can occur before the age of 20 years. SPs were almost all categorized as diffuse plaques (DPs); they did not have amyloid cores and were unaccompanied by neuritic degeneration. In cynomolgus monkeys, SPs (DPs) occur before the appearance of CAA. From the above, it was concluded that cynomolgus monkeys showed pathological changes due to ageing similar to those related to Alzheimer’s disease in humans, even before they were 20 years old.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623309358904