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Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds

A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, activ...

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Published in:	Journal of medicinal chemistry 1979-01, Vol.22 (1), p.28-32
Main Authors:	Zee-Cheng, Robert K. Y, Cheng, C. C
Format:	Article
Language:	English
Subjects:	Animals Antineoplastic Agents - chemical synthesis Leukemia, Experimental - drug therapy Mice Structure-Activity Relationship Thiadiazoles - chemical synthesis Thiadiazoles - pharmacology Thiazoles - chemical synthesis Thiazoles - pharmacology Urea - analogs & derivatives Urea - chemical synthesis Urea - pharmacology
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cited_by	cdi_FETCH-LOGICAL-a268t-ca363b5516296ab8f8095b7d8753b712ea32d7bfebda72a1cda9e4ab6a207b7b3
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container_title	Journal of medicinal chemistry
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creator	Zee-Cheng, Robert K. Y Cheng, C. C
description	A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, active compounds of this series contain either an "isothioureido" [N-C(S-)=N-] or an "isothiosemicarbazono" [N-C(S-)=N-N=] structural unit.
doi_str_mv	10.1021/jm00187a007
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subjects	Animals Antineoplastic Agents - chemical synthesis Leukemia, Experimental - drug therapy Mice Structure-Activity Relationship Thiadiazoles - chemical synthesis Thiadiazoles - pharmacology Thiazoles - chemical synthesis Thiazoles - pharmacology Urea - analogs & derivatives Urea - chemical synthesis Urea - pharmacology
title	Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds
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