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Lack of correlation between cadmium level in local brown rice and renal failure mortality among the residents: a nation-wide analysis in Japan
Objectives Cadmium is a ubiquitous hazardous element with nephro-toxicity after long-term exposure. The present study was initiated to examine possible effects of dietary cadmium (Cd) intake on health of local residents across Japan. For this purpose, Cd in locally harvested brown rice (Cd-BR) was t...
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| Published in: | International archives of occupational and environmental health 2010-03, Vol.83 (3), p.333-339 |
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| container_title | International archives of occupational and environmental health |
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| creator | Koizumi, Naoru Ohashi, Fumiko Ikeda, Masayuki |
| description | Objectives
Cadmium is a ubiquitous hazardous element with nephro-toxicity after long-term exposure. The present study was initiated to examine possible effects of dietary cadmium (Cd) intake on health of local residents across Japan. For this purpose, Cd in locally harvested brown rice (Cd-BR) was taken as the parameter of Cd exposure, and two measures of mortality, i.e., standardized mortality ratio (SMR) and age-adjusted renal insufficiency mortality rate (AARIMR) were employed as parameters of over-all health effects including effects on kidney.
Methods
Japan consists of 47 prefectures. Data on Cd in 37,250 brown rice samples harvested in 1997–1998 in the 47 prefectures were made available from the Ministry of Agriculture, Forestry and Fisheries, Japan. SMR and AARIMR data (for the year 2000) by two genders in the 47 prefectures were cited from publications of the Ministry of Health, Labour and Welfare, Japan. Possible correlation of Cd in brown rice (Cd-BR) with SMR and AARIMR was examined by Poisson regression analysis.
Results
The geometric mean (GM) Cd-BR for Japan as a whole was 0.040 mg/kg with a geometric standard deviation (GSD) of 2.72. Prefectural GM values varied from a low of |
| doi_str_mv | 10.1007/s00420-009-0472-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_744710333</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1963663761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-48962d136e19a647b85225f20ac0267feadad69d05a8f80b017fe4c9344da6033</originalsourceid><addsrcrecordid>eNp1kc-KFDEQxoMo7uzqA3iRIMieWivpTKfb27L4lwEveg7V6eo1azoZk26H2Yfwmc04gwuCp0DVr776Kh9jzwS8EgD6dQZQEiqArgKlZXX3gK2EqmUlpGoeshXUqnRFLc7Yec63AEI3un7MzkTX1krXYsV-bdB-53HkNqZEHmcXA-9p3hEFbnGY3DJxTz_Jcxe4jxY971PcBZ6cJY5h4IlCKY7o_JKITzHN6N285zjFcMPnb1SI7AYKc37DkYc_O6pdqZRx9Pvs8kH7E24xPGGPRvSZnp7eC_b13dsv1x-qzef3H6-vNpVVXTtXqu0aOYi6IdFho3TfrqVcjxLQgmz0SDjg0HQDrLEdW-jL4SMp29VKDdhAXV-wy6PuNsUfC-XZTC5b8h4DxSUbrZQWhTuQL_4hb-OSiu9sJMh1V0y0BRJHyKaYc6LRbJObMO2NAHOIyhyjMiUqc4jK3JWZ5yfhpZ9ouJ84ZVOAlycAc_n2MWGwLv_lZMm4A60LJ49cLq1wQ-ne4f-3_wal4KzW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>202591368</pqid></control><display><type>article</type><title>Lack of correlation between cadmium level in local brown rice and renal failure mortality among the residents: a nation-wide analysis in Japan</title><source>Springer Nature</source><creator>Koizumi, Naoru ; Ohashi, Fumiko ; Ikeda, Masayuki</creator><creatorcontrib>Koizumi, Naoru ; Ohashi, Fumiko ; Ikeda, Masayuki</creatorcontrib><description>Objectives
Cadmium is a ubiquitous hazardous element with nephro-toxicity after long-term exposure. The present study was initiated to examine possible effects of dietary cadmium (Cd) intake on health of local residents across Japan. For this purpose, Cd in locally harvested brown rice (Cd-BR) was taken as the parameter of Cd exposure, and two measures of mortality, i.e., standardized mortality ratio (SMR) and age-adjusted renal insufficiency mortality rate (AARIMR) were employed as parameters of over-all health effects including effects on kidney.
Methods
Japan consists of 47 prefectures. Data on Cd in 37,250 brown rice samples harvested in 1997–1998 in the 47 prefectures were made available from the Ministry of Agriculture, Forestry and Fisheries, Japan. SMR and AARIMR data (for the year 2000) by two genders in the 47 prefectures were cited from publications of the Ministry of Health, Labour and Welfare, Japan. Possible correlation of Cd in brown rice (Cd-BR) with SMR and AARIMR was examined by Poisson regression analysis.
Results
The geometric mean (GM) Cd-BR for Japan as a whole was 0.040 mg/kg with a geometric standard deviation (GSD) of 2.72. Prefectural GM values varied from a low of <0.01 mg/kg to a high of 0.089 mg/kg. Nevertheless, SMR (in a range of 89.9–119.5 for men and 87.1–111.7 for women) did not correlate with Cd-BR significantly. AARIMR (in a range of 5.3–11.9 and 3.2–8.4 for men and women, respectively) tended to decrease as a function of increasing Cd-BR both in men and women, although the correlation was insignificant in both genders.
Conclusions
No evidence was obtained in the present analysis to suggest that either mortality as a whole or the mortality due to renal failure is affected by dietary intake of Cd in rice.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-009-0472-z</identifier><identifier>PMID: 19834731</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Biological and medical sciences ; Cadmium ; Cadmium - adverse effects ; Cadmium - analysis ; Chemical and industrial products toxicology. Toxic occupational diseases ; Diet ; Diet - adverse effects ; Earth and Environmental Science ; Environment ; Environmental Health ; Female ; Harvesting ; Human exposure ; Humans ; Japan - epidemiology ; Kidney diseases ; Male ; Medical sciences ; Metals and various inorganic compounds ; Mortality ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Occupational Medicine/Industrial Medicine ; Original Article ; Oryza - adverse effects ; Oryza - chemistry ; Oryza sativa ; Regression analysis ; Rehabilitation ; Renal failure ; Renal Insufficiency - epidemiology ; Renal Insufficiency - mortality ; Rice ; Toxicology</subject><ispartof>International archives of occupational and environmental health, 2010-03, Vol.83 (3), p.333-339</ispartof><rights>Springer-Verlag 2009</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-48962d136e19a647b85225f20ac0267feadad69d05a8f80b017fe4c9344da6033</citedby><cites>FETCH-LOGICAL-c498t-48962d136e19a647b85225f20ac0267feadad69d05a8f80b017fe4c9344da6033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22469077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19834731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koizumi, Naoru</creatorcontrib><creatorcontrib>Ohashi, Fumiko</creatorcontrib><creatorcontrib>Ikeda, Masayuki</creatorcontrib><title>Lack of correlation between cadmium level in local brown rice and renal failure mortality among the residents: a nation-wide analysis in Japan</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><addtitle>Int Arch Occup Environ Health</addtitle><description>Objectives
Cadmium is a ubiquitous hazardous element with nephro-toxicity after long-term exposure. The present study was initiated to examine possible effects of dietary cadmium (Cd) intake on health of local residents across Japan. For this purpose, Cd in locally harvested brown rice (Cd-BR) was taken as the parameter of Cd exposure, and two measures of mortality, i.e., standardized mortality ratio (SMR) and age-adjusted renal insufficiency mortality rate (AARIMR) were employed as parameters of over-all health effects including effects on kidney.
Methods
Japan consists of 47 prefectures. Data on Cd in 37,250 brown rice samples harvested in 1997–1998 in the 47 prefectures were made available from the Ministry of Agriculture, Forestry and Fisheries, Japan. SMR and AARIMR data (for the year 2000) by two genders in the 47 prefectures were cited from publications of the Ministry of Health, Labour and Welfare, Japan. Possible correlation of Cd in brown rice (Cd-BR) with SMR and AARIMR was examined by Poisson regression analysis.
Results
The geometric mean (GM) Cd-BR for Japan as a whole was 0.040 mg/kg with a geometric standard deviation (GSD) of 2.72. Prefectural GM values varied from a low of <0.01 mg/kg to a high of 0.089 mg/kg. Nevertheless, SMR (in a range of 89.9–119.5 for men and 87.1–111.7 for women) did not correlate with Cd-BR significantly. AARIMR (in a range of 5.3–11.9 and 3.2–8.4 for men and women, respectively) tended to decrease as a function of increasing Cd-BR both in men and women, although the correlation was insignificant in both genders.
Conclusions
No evidence was obtained in the present analysis to suggest that either mortality as a whole or the mortality due to renal failure is affected by dietary intake of Cd in rice.</description><subject>Biological and medical sciences</subject><subject>Cadmium</subject><subject>Cadmium - adverse effects</subject><subject>Cadmium - analysis</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Diet</subject><subject>Diet - adverse effects</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Health</subject><subject>Female</subject><subject>Harvesting</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oryza - adverse effects</subject><subject>Oryza - chemistry</subject><subject>Oryza sativa</subject><subject>Regression analysis</subject><subject>Rehabilitation</subject><subject>Renal failure</subject><subject>Renal Insufficiency - epidemiology</subject><subject>Renal Insufficiency - mortality</subject><subject>Rice</subject><subject>Toxicology</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kc-KFDEQxoMo7uzqA3iRIMieWivpTKfb27L4lwEveg7V6eo1azoZk26H2Yfwmc04gwuCp0DVr776Kh9jzwS8EgD6dQZQEiqArgKlZXX3gK2EqmUlpGoeshXUqnRFLc7Yec63AEI3un7MzkTX1krXYsV-bdB-53HkNqZEHmcXA-9p3hEFbnGY3DJxTz_Jcxe4jxY971PcBZ6cJY5h4IlCKY7o_JKITzHN6N285zjFcMPnb1SI7AYKc37DkYc_O6pdqZRx9Pvs8kH7E24xPGGPRvSZnp7eC_b13dsv1x-qzef3H6-vNpVVXTtXqu0aOYi6IdFho3TfrqVcjxLQgmz0SDjg0HQDrLEdW-jL4SMp29VKDdhAXV-wy6PuNsUfC-XZTC5b8h4DxSUbrZQWhTuQL_4hb-OSiu9sJMh1V0y0BRJHyKaYc6LRbJObMO2NAHOIyhyjMiUqc4jK3JWZ5yfhpZ9ouJ84ZVOAlycAc_n2MWGwLv_lZMm4A60LJ49cLq1wQ-ne4f-3_wal4KzW</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Koizumi, Naoru</creator><creator>Ohashi, Fumiko</creator><creator>Ikeda, Masayuki</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7TV</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20100301</creationdate><title>Lack of correlation between cadmium level in local brown rice and renal failure mortality among the residents: a nation-wide analysis in Japan</title><author>Koizumi, Naoru ; Ohashi, Fumiko ; Ikeda, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-48962d136e19a647b85225f20ac0267feadad69d05a8f80b017fe4c9344da6033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Cadmium</topic><topic>Cadmium - adverse effects</topic><topic>Cadmium - analysis</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Diet</topic><topic>Diet - adverse effects</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Environmental Health</topic><topic>Female</topic><topic>Harvesting</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oryza - adverse effects</topic><topic>Oryza - chemistry</topic><topic>Oryza sativa</topic><topic>Regression analysis</topic><topic>Rehabilitation</topic><topic>Renal failure</topic><topic>Renal Insufficiency - epidemiology</topic><topic>Renal Insufficiency - mortality</topic><topic>Rice</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koizumi, Naoru</creatorcontrib><creatorcontrib>Ohashi, Fumiko</creatorcontrib><creatorcontrib>Ikeda, Masayuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Pollution Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koizumi, Naoru</au><au>Ohashi, Fumiko</au><au>Ikeda, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of correlation between cadmium level in local brown rice and renal failure mortality among the residents: a nation-wide analysis in Japan</atitle><jtitle>International archives of occupational and environmental health</jtitle><stitle>Int Arch Occup Environ Health</stitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>83</volume><issue>3</issue><spage>333</spage><epage>339</epage><pages>333-339</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>Objectives
Cadmium is a ubiquitous hazardous element with nephro-toxicity after long-term exposure. The present study was initiated to examine possible effects of dietary cadmium (Cd) intake on health of local residents across Japan. For this purpose, Cd in locally harvested brown rice (Cd-BR) was taken as the parameter of Cd exposure, and two measures of mortality, i.e., standardized mortality ratio (SMR) and age-adjusted renal insufficiency mortality rate (AARIMR) were employed as parameters of over-all health effects including effects on kidney.
Methods
Japan consists of 47 prefectures. Data on Cd in 37,250 brown rice samples harvested in 1997–1998 in the 47 prefectures were made available from the Ministry of Agriculture, Forestry and Fisheries, Japan. SMR and AARIMR data (for the year 2000) by two genders in the 47 prefectures were cited from publications of the Ministry of Health, Labour and Welfare, Japan. Possible correlation of Cd in brown rice (Cd-BR) with SMR and AARIMR was examined by Poisson regression analysis.
Results
The geometric mean (GM) Cd-BR for Japan as a whole was 0.040 mg/kg with a geometric standard deviation (GSD) of 2.72. Prefectural GM values varied from a low of <0.01 mg/kg to a high of 0.089 mg/kg. Nevertheless, SMR (in a range of 89.9–119.5 for men and 87.1–111.7 for women) did not correlate with Cd-BR significantly. AARIMR (in a range of 5.3–11.9 and 3.2–8.4 for men and women, respectively) tended to decrease as a function of increasing Cd-BR both in men and women, although the correlation was insignificant in both genders.
Conclusions
No evidence was obtained in the present analysis to suggest that either mortality as a whole or the mortality due to renal failure is affected by dietary intake of Cd in rice.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19834731</pmid><doi>10.1007/s00420-009-0472-z</doi><tpages>7</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Biological and medical sciences Cadmium Cadmium - adverse effects Cadmium - analysis Chemical and industrial products toxicology. Toxic occupational diseases Diet Diet - adverse effects Earth and Environmental Science Environment Environmental Health Female Harvesting Human exposure Humans Japan - epidemiology Kidney diseases Male Medical sciences Metals and various inorganic compounds Mortality Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Occupational Medicine/Industrial Medicine Original Article Oryza - adverse effects Oryza - chemistry Oryza sativa Regression analysis Rehabilitation Renal failure Renal Insufficiency - epidemiology Renal Insufficiency - mortality Rice Toxicology |
| title | Lack of correlation between cadmium level in local brown rice and renal failure mortality among the residents: a nation-wide analysis in Japan |
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