Clinical trial: normal diet vs. partial replacement with oral E028 formula for the prevention of gastrointestinal toxicity in cancer patients undergoing pelvic radiotherapy

Summary Background  Acute gastrointestinal symptoms affect 90% of patients during pelvic radiotherapy. Elemental diet is protective in animal models. A nonrandomized study suggested benefit from a partial elemental diet. A pilot study suggested that radiotherapy patients only tolerate oral elemental...

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Published in:Alimentary pharmacology & therapeutics 2008-06, Vol.27 (11), p.1132-1139
Main Authors: MCGOUGH, C., WEDLAKE, L., BALDWIN, C., HACKETT, C., NORMAN, A. R., BLAKE, P., HARRINGTON, K., TAIT, D., KHOO, V., FROST, G., ANDREYEV, H. J. N.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Diarrhea - prevention & control
Digestive system
Energy Intake
Enteral Nutrition - methods
Female
Food, Formulated
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Tract - radiation effects
Humans
Male
Medical sciences
Middle Aged
Nutritional Requirements
Pelvic Neoplasms - radiotherapy
Pharmacology. Drug treatments
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Summary Background  Acute gastrointestinal symptoms affect 90% of patients during pelvic radiotherapy. Elemental diet is protective in animal models. A nonrandomized study suggested benefit from a partial elemental diet. A pilot study suggested that radiotherapy patients only tolerate oral elemental diet comprising one‐third of total calories for 3 weeks. Aim  To assess the feasibility and efficacy of replacing one‐third of normal diet with elemental diet during the first 3 weeks of pelvic radiotherapy in reducing acute gastrointestinal toxicity. Methods  Patients were randomized to elemental diet or no intervention. Toxicity was assessed using the Inflammatory Bowel Disease Questionnaire, Vaizey Incontinence scale and Radiation Therapy Oncology Group tool. Faecal calprotectin measured intestinal mucosal inflammation. Results  Twenty‐nine women and 21 men, median age 61.5 years were randomized. Patients taking elemental diet did not have lower gastrointestinal toxicity ratings or inflammatory markers (P > 0.2). The mean dose taken was 21% (2–36%) of total caloric requirements. Conclusions  Patients cannot tolerate large volumes of oral elemental diet. The quantities consumed in this study produced no therapeutic benefit. Future studies should aim to replace a higher proportion of nutritional intake for a longer duration of radiotherapy treatment.
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2008.03665.x