Methylation of the DCC Gene Is Lost in Advanced Gastric Cancer

Background: Deleted in colorectal carcinoma (DCC), one of the Netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, we examined the methylation status of the DCC gene in colorectal c...

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Bibliographic Details
Published in:Anticancer research 2010-01, Vol.30 (1), p.107-109
Main Authors: HIBI, Kenji, SAKATA, Makiko, NEMOTO, Hiroshi, SANADA, Yutaka, SAKURABA, Kazuma, KITAMURA, Yo-Hei, SHIRAHATA, Atsushi, GOTO, Tetsuhiro, MIZUKAMI, Hiroki, SAITO, Mitsuo, ISHIBASHI, Kazuyoshi, KIGAWA, Gaku
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
DNA Methylation
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genes, DCC
Humans
Male
Medical sciences
Middle Aged
Neoplasm Staging
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Background: Deleted in colorectal carcinoma (DCC), one of the Netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, we examined the methylation status of the DCC gene in colorectal carcinomas and found that aberrant methylation of the DCC gene was detected in 28 out of the 50 (56%) primary colon carcinomas. This result prompted us to examine the methylation status of the DCC gene in gastric carcinoma. Materials and Methods: The methylation status of the DCC gene was examined in primary carcinomas and the corresponding normal tissues derived from 36 patients with gastric cancer using quantitative methylation-specific polymerase chain reaction (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated. Results. Aberrant methylation of the DCC gene was detected in 16 out of the 36 (44%) primary gastric carcinomas. A significant difference was observed in regard to the TNM stage (p=0.0093). Conclusion: DCC methylation was observed in the course of gastric carcinogenesis and disappeared in advanced gastric carcinoma.
ISSN:0250-7005
1791-7530