Cellular stress and RNA splicing

In response to physical and chemical stresses that affect protein folding and, thus, the execution of normal metabolic processes, cells activate gene-expression strategies aimed at increasing their chance of survival. One target of several stressing agents is pre-mRNA splicing, which is inhibited up...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2009-03, Vol.34 (3), p.146-153
Main Authors: Biamonti, Giuseppe, Caceres, Javier F.
Format: Article
Language:English
Subjects:
Animals
Cell Cycle Proteins - metabolism
Humans
Models, Biological
Neoplasm Proteins - metabolism
Repressor Proteins - metabolism
RNA Precursors - metabolism
RNA Splicing - genetics
RNA Splicing - physiology
RNA-Binding Proteins - metabolism
Serine-Arginine Splicing Factors
Stress, Physiological - physiology
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Summary:In response to physical and chemical stresses that affect protein folding and, thus, the execution of normal metabolic processes, cells activate gene-expression strategies aimed at increasing their chance of survival. One target of several stressing agents is pre-mRNA splicing, which is inhibited upon heat shock. Recently, the molecular basis of this splicing inhibition has begun to emerge. Interestingly, different mechanisms seem to be in place to block constitutive pre-mRNA splicing and to affect alternative splicing regulation. This could be important to modulate gene expression during recovery from stress. Thus, pre-mRNA splicing emerges as a central mechanism to integrate cellular and metabolic stresses into gene-expression profiles.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2008.11.004