Diabetes Mellitus Increases the Risk of Mortality Following Liver Transplantation Independent of MELD Score

• Published in: Digestive diseases and sciences 2010-07, Vol.55 (7), p.2089-2094
• Main Authors: Samuelson, Andrew L, Lee, Maximilian, Kamal, Ahmad, Keeffe, Emmet B, Ahmed, Aijaz
• Format: Article
• Language: English
• Subjects: Age Factors; Biochemistry; Biological and medical sciences; Case-Control Studies; Cause of Death; Diabetes Mellitus - diagnosis; Diabetes Mellitus - drug therapy; Diabetes Mellitus - mortality; Diabetes. Impaired glucose tolerance; Diabetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Gastroenterology; Health aspects; Hepatitis C; Hepatology; Humans; Kaplan-Meier Estimate; Kidneys; Liver; Liver Failure - surgery; Liver Transplantation - methods; Liver Transplantation - mortality; Liver, biliary tract, pancreas, portal circulation, spleen; Logistic Models; Male; Medical centers; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Mortality; Multivariate Analysis; Oncology; Organ transplant recipients; Original Article; Probability; Retrospective Studies; Risk Assessment; Risk factors; Severity of Illness Index; Sex Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survival Analysis; Transplant Surgery; Transplantation; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-010-1267-5

Background Patients with diabetes mellitus overall experience worse health outcomes than non-diabetics, but whether this is true among recipients of liver transplantation still remains unclear. The aim of this study was to compare the mortality of diabetic and non-diabetic patients following liver transplantation. Methods We conducted a retrospective analysis of 530 adult patients undergoing liver transplantation at Stanford University Medical Center from February 1995 to July 2006. Information on diabetes mellitus was available for 431 patients; 96 patients who had acute liver failure (n = 17), combined liver and kidney transplantation (n = 28), or died prior to discharge (n = 51) were excluded from analysis. Results Over a mean follow-up of 4.5 years, survival was 81% in the diabetic group and 94% among controls (p =