A possible mechanism for insulin resistance and hyperglycaemia in NZO mice

THE New Zealand obese (NZO) mouse is characterised by obesity, hyperinsulinaemia, insulin resistance and mild glucose intolerance 1–8 . It has been thought of as a model of the adult-type human diabetes mellitus, but neither the genetics of the NZO syndrome nor its basic cause have been elucidated....

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Bibliographic Details
Published in:Nature (London) 1979-05, Vol.279 (5711), p.334-336
Main Authors: HARRISON, LEN C., ITIN, AHUVA
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - analysis
Autoimmune Diseases - immunology
Humanities and Social Sciences
Hyperglycemia - immunology
Insulin - metabolism
Insulin Antagonists
letter
Liver - metabolism
Mice
Mice, Obese - immunology
multidisciplinary
Receptor, Insulin - immunology
Receptor, Insulin - metabolism
Science
Science (multidisciplinary)
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Summary:THE New Zealand obese (NZO) mouse is characterised by obesity, hyperinsulinaemia, insulin resistance and mild glucose intolerance 1–8 . It has been thought of as a model of the adult-type human diabetes mellitus, but neither the genetics of the NZO syndrome nor its basic cause have been elucidated. The metabolic disturbances found in these mice, for example increased rates of lipogenesis 9–12 and defects in insulin secretion 8,13,14 , could well be secondary to chronic hyperinsulinaemia and hyperglycaemia. Because the NZO strain appeared to share a common ancestry with the NZB model of systemic autoimmune disease 1,2,15 we felt that the metabolic syndrome in the NZO mouse might have an immune basis. It was originally suggested that the insulin resistance of NZO mice might be due to an antagonist to the action of insulin 2 . We now report that NZO serum contains a globulin, probably an autoantibody, which inhibits insulin binding and indirectly immunoprecipitates the solubilised insulin receptor.
ISSN:0028-0836
1476-4687
DOI:10.1038/279334a0