The neurobiological substrates of behavioral manifestations during temporal lobe seizures: A neuroethological and ictal SPECT correlation study

Abstract Ictal behavior coupled with SPECT findings during 28 seizures in patients with temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (13 left; 15 right) was displayed as flowcharts from right-sided (RTLE) plus left-sided (LTLE) seizures. Ictal SPECT was classified blind to neur...

Full description

Saved in:
Bibliographic Details
Published in:Epilepsy & behavior 2010-03, Vol.17 (3), p.344-353
Main Authors: Bertti, Poliana, Dal-Cól, Maria Luiza Cleto, Wichert-Ana, Lauro, Kato, Mery, Terra, Vera Cristina, de Oliveira, José Antônio Cortes, Velasco, Tonicarlo Rodrigues, Sakamoto, Américo Ceiki, Garcia-Cairasco, Norberto
Format: Article
Language:English
Subjects:
Basal ganglia
Basal Ganglia - diagnostic imaging
Basal Ganglia - pathology
Behavior - physiology
Brain Mapping
Cerebrovascular Circulation - physiology
Dystonic posturing
Electroencephalography - methods
Epilepsy, Temporal Lobe - diagnostic imaging
Epilepsy, Temporal Lobe - physiopathology
Epileptic seizures
Female
Functional Laterality - physiology
Hippocampus - pathology
Humans
Magnetic Resonance Imaging
Male
Neurobiology - methods
Neurology
Nuclear medicine
Retrospective Studies
Sclerosis - etiology
Sclerosis - pathology
Semiology
Statistics as Topic
Tomography, Emission-Computed, Single-Photon
Video Recording - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Ictal behavior coupled with SPECT findings during 28 seizures in patients with temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (13 left; 15 right) was displayed as flowcharts from right-sided (RTLE) plus left-sided (LTLE) seizures. Ictal SPECT was classified blind to neuroethology. Behaviors were categorized as ipsilateral to the epileptogenic zone (IL), contralateral to the epileptogenic zone (CL), or bilateral. SPECT intensity and region were categorized as IL or CL to the epileptogenic zone. All patients developed automatisms and had hyperperfusion in their temporal lobes. Patients’ verbal responses to questions had statistical interactions in RTLE but not in LTLE sum. Most CL dystonic posturing was correlated to IL basal ganglia hyperperfusion. Basal ganglia activation occurred in seizures without dystonic posturing and CL manual automatisms, and lack of IL dystonic posturing and the presence of CL cerebellar hemispheric hyperperfusion were also observed. Coupling of neuroethology and SPECT findings reliably evaluates ictal behavior and functionality of associated brain areas.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2009.12.030