Biochemical and hormonal changes in endurance trained volunteers during and after exposure to bed rest and chronic hyperhydration

• Published in: Acta astronautica 2000-04, Vol.46 (8), p.541-550
• Main Authors: Zorbas, Y.G, Naexu, K.A, Yaroshenko, Y.N
• Format: Article
• Language: English
• Subjects: Adult; Aldosterone - blood; Aldosterone - metabolism; Bed Rest; Biochemistry; Body Weight; Cyclic AMP - blood; Cyclic AMP - metabolism; Cyclic GMP - blood; Cyclic GMP - metabolism; Fluid Therapy; Hormones; Human engineering; Humans; Male; Oxygen Consumption - physiology; Physical Fitness - physiology; Prostaglandins - blood; Prostaglandins - metabolism; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; Sodium Chloride - pharmacology; Space life sciences; Water-Electrolyte Balance - drug effects; Water-Electrolyte Balance - physiology
• ISSN: 0094-5765; 1879-2030
• DOI: 10.1016/S0094-5765(00)00004-7

The objective of this investigation was to assess the effect of a daily intake of fluid and salt supplementation on biochemical and hormonal changes in endurance trained volunteers aged 19–24 yrs during 30-day bed rest and during 15 days of post bed rest period. The studies were performed on 30 long distance runners aged 19–24 yrs who had a peak oxygen uptake of 66 ml/kg/min and had taken 14.5 km/day on average prior to their participation in the study. The volunteers were divided into three groups: the volunteers in the first group were under normal ambulatory conditions (control subjects); the second group subjected to bed rest alone unsupplemented (bed rested volunteers); the third group was submitted to bed rest and consumed daily 30 ml water/kg bodyweight and 0.1 g of sodium chloride (NaCl)/kg body weight (supplemented bed rested volunteers). The second and third groups of volunteers were kept under a rigorous bed rest regime for 30 days. During the pre bed rest period of 15 days, during the bed rest period of 30 days and during the post bed rest period of 15 days cyclic adenosine monophosphate, cyclic guanosine monophosphate, prostaglandins of pressor, prostaglandins depressor groups, renin activity in plasma and aldosterone in plasma and in urine were determined. We found that in bed rested volunteers without fluid and salt supplementation intake plasma renin activity and aldosterone in plasma and urine continued to increase during the bed rest period as plasma volume decreased. Moreover, in this group, cyclic nucleotides measured as an indicator of adrenosympathetic system activity increased and prostaglandins as local vasoactive substances decreased during the bed rest period. These variables returned toward the baselines in the post bed rest period as plasma volume deficit was restituted. On the other hand, the hormonal levels in the other two groups remained rather constant during the experimental period. We concluded that daily intake of fluid and salt supplementation may minimize the biochemical and hormonal changes in endurance trained volunteers during their exposure to bed rest conditions.