HIV-Unrelated Benign Lymphoepithelial Cyst of the Parotid Glands Containing Lymphoepithelial Lesion—Like Structures: A Report of 3 Cases

Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structu...

Full description

Saved in:
Bibliographic Details
Published in:International journal of surgical pathology 2009-12, Vol.17 (6), p.421-425
Main Authors: Kojima, Masaru, Nakamura, Naoya, Matsuda, Hazuki, Kaba, Sadayuki, Itoh, Hideaki, Masawa, Nobuhide
Format: Article
Language:English
Subjects:
Adult
Biomarkers - metabolism
Cysts - metabolism
Cysts - pathology
Cysts - surgery
Diagnosis, Differential
Epithelial Cells - metabolism
Epithelial Cells - pathology
Female
HIV Infections - pathology
Human immunodeficiency virus 1
Humans
Lymphocytes - metabolism
Lymphocytes - pathology
Lymphoma, B-Cell, Marginal Zone - diagnosis
Lymphoproliferative Disorders - metabolism
Lymphoproliferative Disorders - pathology
Lymphoproliferative Disorders - surgery
Male
Middle Aged
Parotid Diseases - metabolism
Parotid Diseases - pathology
Parotid Diseases - surgery
Parotid Gland - metabolism
Parotid Gland - pathology
Parotid Gland - surgery
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically, 3 lesions were characterized by cuboidal epithelial-lined, cystic spaces, numerous lymphoid follicles, and dense lymphoplasmacytoid infiltrate. Moreover, small lymphocytes invaded the epithelial clusters forming LeL-like structures. Histological findings of 3 lesions resembled marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. However, staining with CD3, CD5, and CD20 demonstrated the mixed nature of small lymphocytes invading the epithelial clusters (LeLlike structures). Moreover, there were no CD43+ B-lymphocytes in any of the cases. The polytypic nature of B-lymphocytes was demonstrated by immunohistochemistry and polymerase chain reaction. The 3 cases indicate that HIV-unrelated BLC should be added to the differential diagnosis of MALT-type lymphoma involving the parotid glands.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896908328575