Failure of alpha tocopherol to influence chest pain in patients with heart disease

Claims for vitamin E in angina pectoris have not been based on controlled observations. Even some negative reports have not been adequately controlled as to nonspecific factors. Hence, this study of the effects of alpha tocopherol on cardiac pain used a method of investigation carefully controlled a...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1950-02, Vol.1 (2), p.288-293
Main Authors: RINZLER, S H, BAKST, H
Format: Article
Language:English
Subjects:
alpha-Tocopherol
Chest Pain
Heart
Heart Diseases
Humans
Old Medline
Thorax
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Claims for vitamin E in angina pectoris have not been based on controlled observations. Even some negative reports have not been adequately controlled as to nonspecific factors. Hence, this study of the effects of alpha tocopherol on cardiac pain used a method of investigation carefully controlled as to psychologic factors which might affect the patient's response or the examiner's interpretation of results. The dose of synthetic alpha tocopherol acetate (300 mg. by mouth daily for two or more months) was the same as that recommended by advocates of this form of therapy as optimum in most cases. The results failed to indicate that the vitamin possessed any advantage over the placebo for treatment of either effort angina or mixed types of cardiac and somatic chest pain.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.1.2.288