Cell-mediated immunity in the liver of mice vaccinated against malaria

Mice can be protected against several species of lethal malaria infection by vaccination 1 , and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-ty...

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Bibliographic Details
Published in:Nature (London) 1979-12, Vol.282 (5740), p.731-734
Main Authors: Playfair, J. H. L, De Souza, J. B, Dockrell, H. M, Agomo, P. U, Taverne, J
Format: Article
Language:English
Subjects:
Animals
Cytotoxicity, Immunologic
Humanities and Social Sciences
Hypersensitivity, Delayed - immunology
Immunity, Cellular
letter
Leukocytes - immunology
Liver - immunology
Malaria - immunology
Malaria - prevention & control
Mice
multidisciplinary
Plasmodium berghei - immunology
Science
Science (multidisciplinary)
Spleen - immunology
Vaccination
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Summary:Mice can be protected against several species of lethal malaria infection by vaccination 1 , and their recovery correlates well with increased anti-malarial antibody levels, particularly IgG (ref. 2). However, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin 3–5 , although there is no obvious explanation for this effect. We now report an apparent relationship between protection and a cell-mediated immune response involving the migration of various types of cell capable of killing malaria parasites in vitro to the liver. We suggest that the effect of vaccination is to bring together parasites, specific antibody and nonspecific cytotoxic cells, and that the liver may be a major site for their interaction.
ISSN:0028-0836
1476-4687
DOI:10.1038/282731a0