Impact of CPAP treatment on cardiac biomarkers and pro-BNP in obstructive sleep apnea syndrome

Objective To evaluate the effect of continuous positive airway pressure (CPAP) therapy on pro-brain natriuretic peptide (BNP) and cardiac markers in patients with obstructive sleep apnea syndrome and normal cardiac function. Methods Thirty-three consecutive patients with sleep apnea syndrome were an...

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Bibliographic Details
Published in:Sleep & breathing 2010-09, Vol.14 (3), p.241-244
Main Authors: Çifçi, Nilüfer, Uyar, Meral, Elbek, Osman, Süyür, Hüseyin, Ekinci, Erhan
Format: Article
Language:English
Subjects:
Adult
Aspartate Aminotransferases - blood
Biomarkers
Cardiovascular system
Continuous Positive Airway Pressure
Creatine Kinase - blood
Creatine Kinase, MB Form - blood
Dentistry
Female
Humans
Internal Medicine
Male
Medical treatment
Medicine
Medicine & Public Health
Middle Aged
Natriuretic Peptide, Brain - blood
Neurology
Original Article
Otorhinolaryngology
Pediatrics
Peptides
Pneumology/Respiratory System
Polysomnography
Prospective Studies
Protein Precursors - blood
Reference Values
Sleep apnea
Sleep Apnea, Obstructive - blood
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - therapy
Troponin I - blood
Ventilators
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Summary:Objective To evaluate the effect of continuous positive airway pressure (CPAP) therapy on pro-brain natriuretic peptide (BNP) and cardiac markers in patients with obstructive sleep apnea syndrome and normal cardiac function. Methods Thirty-three consecutive patients with sleep apnea syndrome were analysed for serum pro-BNP and cardiac markers prior to and after 6 months of CPAP therapy. Results Twenty five patients had normal (83.3%) while remaining five (16.7%) revealed high pro-BNP values. We did not detect any significant difference between severity of obstructive sleep apnea syndrome and serum pro-BNP levels ( p  = 0.534). A statistically significant difference was not observed between basal and sixth-month creatine kinase (CK), creatine kinase-MB (CK-MB), troponin I, pro-BNP, aspartate transaminase (AST), and CK levels in patients with sleep apnea syndrome ( p  > 0.05). Conclusion Obstructive sleep apnea syndrome does not induce myocardial damage enough to increase serum pro-BNP, CK, CK-MB, troponin I, and AST levels. Markers sensitive to ischemia could be preferred to evaluate effect of obstructive sleep apnea syndrome.
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-009-0306-y