Preserved Immune Functions and Controlled Leukocyte Oxidative Stress in Naturally Long-lived Mice: Possible Role of Nuclear Factor Kappa B

In order to verify the survival biomarker role of several immune functions, and to determine the oxidation and inflammation mechanisms underlying variability in the aging process, we have investigated a variety of immune functions and oxidative stress parameters as well as activation of the nuclear...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2010-09, Vol.65A (9), p.941-950
Main Authors: Arranz, Lorena, Caamaño, Jorge H., Lord, Janet M., De la Fuente, Mónica
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Biomarkers
Catalase - metabolism
Cell Proliferation
Cells
Cross-Sectional Studies
Enzyme kinetics
Female
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Immune function
Interleukin-2 - metabolism
Leukocytes
Leukocytes - metabolism
Longevity
Macrophages, Peritoneal - physiology
Mice
Mice, Inbred ICR
NF-kappa B - metabolism
NFκB
Oxidation
Oxidative stress
Oxidative Stress - immunology
Peritoneum - cytology
Phagocytosis
Reactive Oxygen Species
Rodents
Xanthine Oxidase - metabolism
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Summary:In order to verify the survival biomarker role of several immune functions, and to determine the oxidation and inflammation mechanisms underlying variability in the aging process, we have investigated a variety of immune functions and oxidative stress parameters as well as activation of the nuclear factor kappa B (NFκB) in peritoneal leukocytes from four different age groups of mice, including natural extreme longevity. Immune cells from naturally long-lived animals showed preservation of immune function in response to stimuli and controlled oxidative stress as well as nuclear factor kappa B activation in resting conditions. Moreover, leukocytes from extreme long-lived animals showed increased catalase activity when compared with the adults. In contrast, the old and very old animal groups showed impaired immune function and increased oxidation as well as NFκB activation. Our results support preserved immune function as a biomarker of extended survival and point to controlled regulation of NFκB activity as a key mechanism restraining oxidative stress in immune cells and contributing to reach longevity.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glq101