Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives

• Published in: European journal of medicinal chemistry 2010-09, Vol.45 (9), p.4074-4078
• Main Authors: Biradar, J.S., Sasidhar, B.S., Parveen, R.
• Format: Article
• Language: English
• Subjects: Antioxidant activity; Barbituric acid; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Chalcones; DNA - metabolism; DNA cleavage activity; Drug Discovery; Free Radical Scavengers - chemical synthesis; Free Radical Scavengers - chemistry; Free Radical Scavengers - metabolism; Free Radical Scavengers - pharmacology; Free Radicals - chemistry; Indole-3-carboxaldehyde; Indoles - chemical synthesis; Indoles - chemistry; Indoles - metabolism; Indoles - pharmacology; Iron - chemistry; Medical sciences; Pharmacology. Drug treatments; Vilsmeier–Haack formylation
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2010.05.067

A new series of novel indole derivatives containing barbitone moiety ( 5a- i) are synthesized by simple and efficient condensation of chalcones ( 3a- i) with barbituric acid ( 4). The synthesized compounds are screened for their antioxidant (free radical scavenging, total antioxidant capacity and ferric reducing antioxidant power) and DNA cleavage activities were evaluated. Among the synthesized compounds ( 5a), ( 5d) and ( 5g) exhibited excellent antioxidant activity and all the tested compounds in the series have exhibited promising DNA cleavage activities. The structures of the synthesized compounds are assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. A new series of novel indole analogues are evaluated for their antioxidant and DNA cleavage activities. [Display omitted]