Effect of acute administration of cadmium on the disposition of copper, zinc, and iron in the rat

Acute administration of subcutaneous doses of cadmium (0.1–1.5 mg/kg) to male rats resulted in high plasma concentrations of copper 24 hr after treatment. In contrast, plasma zinc and iron levels were markedly reduced. The magnitude and significance of the changes in plasma metal ion concentrations...

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Bibliographic Details
Published in:Environmental research 1980-02, Vol.21 (1), p.177-185
Main Authors: Ashby, S.L., King, L.J., Parke, D.V.W.
Format: Article
Language:English
Subjects:
Animals
Bile - metabolism
Cadmium - administration & dosage
Ceruloplasmin - blood
Ceruloplasmin - metabolism
Copper - blood
Copper - metabolism
Dose-Response Relationship, Drug
Iron - blood
Iron - metabolism
Liver - metabolism
Male
Rats
Zinc - blood
Zinc - metabolism
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Summary:Acute administration of subcutaneous doses of cadmium (0.1–1.5 mg/kg) to male rats resulted in high plasma concentrations of copper 24 hr after treatment. In contrast, plasma zinc and iron levels were markedly reduced. The magnitude and significance of the changes in plasma metal ion concentrations were dependent upon the dose of cadmium administered. Liver copper levels were slightly but not significantly increased, but circulating ceruloplasmin levels increased as the total plasma copper increased. Biliary excretion of copper was markedly inhibited after cadmium administration (subcutaneous and oral) and the degree of inhibition was directly related to the dose. Simultaneous parenteral administration of zinc did not counteract this effect. These results suggest that cadmium blocks the excretion of copper into the bile leading to an accumulation of copper in the liver, which in turn, stimulates the synthesis of ceruloplasmin. The mechanisms by which cadmium may inhibit biliary copper excretion are discussed.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(80)90019-5