Voltammetric assay of anti-vertigo drug betahistine hydrochloride in sodium lauryl sulphate

Assay and electrochemical behaviour of betahistine hydrochloride in Britton–Robinsons (BR) buffer of pH range 2.5–12.0 at a glassy carbon electrode have been investigated. Addition of anionic surfactant (sodium lauryl sulphate) to the betahistine hydrochloride solution containing electrolyte enhance...

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Bibliographic Details
Published in:Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2010-08, Vol.366 (1), p.63-67
Main Authors: Jain, Rajeev, Yadav, Rajeev Kumar, Rather, Jahangir Ahmad
Format: Article
Language:English
Subjects:
Assaying
Betahistine hydrochloride
Chemistry
Electrochemistry
Electrodes
Exact sciences and technology
Formulations
General and physical chemistry
Glassy carbon electrode
HPLC
Hydrochlorides
Pharmaceutical formulation
Pharmaceuticals
Reduction (electrolytic)
Sodium dodecyl sulfate
Surfactant
Surfactants
Voltammetry
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Summary:Assay and electrochemical behaviour of betahistine hydrochloride in Britton–Robinsons (BR) buffer of pH range 2.5–12.0 at a glassy carbon electrode have been investigated. Addition of anionic surfactant (sodium lauryl sulphate) to the betahistine hydrochloride solution containing electrolyte enhanced the reduction current signal while neutral surfactant (Tween-20) and cationic surfactant cetyl trimethylammonium bromide (CTAB) showed an opposite effect. Voltammograms of betahistine hydrochloride exhibited a single wave. Based on reduction behaviour of betahistine hydrochloride, a direct square-wave voltammetric method has been developed for the assay of betahistine hydrochloride in pharmaceutical formulation. The proposed method has been validated as per ICH guideline. System and method precision in terms of RSD were 1.88% and 1.60% respectively, whereas the method accuracy was indicated by the recovery of 97.6–101.9%. Reduction peak current was linear over the target concentration with correlation coefficient 0.998. The proposed method was successfully applied to the determination of betahistine hydrochloride in pharmaceutical formulation. The results were compared with those obtained by the reference high performance liquid chromatographic method. No significant differences were found between results of proposed and reference methods.
ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2010.05.027