Vagal and sympathetic reflexes of left ventricular origin on the efferent activity of cardiac and renal nerves on anaesthetized cats

• Published in: Basic research in cardiology 1980-09, Vol.75 (5), p.635-645
• Main Authors: Vogt, A, Thämer, V
• Format: Article
• Language: English
• Subjects: Animals; Aorta - physiopathology; Arterial Occlusive Diseases - physiopathology; Cats; Coronary Vessels - physiopathology; Heart - innervation; Heart Rate; Heart Ventricles - innervation; Heart Ventricles - physiopathology; Kidney - innervation; Reflex - physiology; Sympathetic Nervous System - physiology; Vagus Nerve - physiology
• ISSN: 0300-8428; 1435-1803
• DOI: 10.1007/BF01907693

The influence of reflexes of left ventricular origin on the postganglionic sympathetic activity and heart rate was investigated in anaesthetized cats. The experiments were to clarify 1. whether there are regionally different reflex adjustments due to an activation of ventricular receptors, 2. whether an increase of left ventricular diastolic pressure, which is known to activate afferent vagal fibres, causes an inhibition of sympathetic activity, 3. whether a coronary artery occlusion can activate a pressor reflex and a depressor reflex. Left ventricular receptors were stimulated by obstruction of the aortic root, coronary artery occlusion and mechanical stretch of the ventricular wall. In animals with intact CNS, all stimuli led to an inhibition of the activity of the inferior cardiac and renal sympathetic nerves and bradycardia. These reflex effects are initiated by mechanoreceptors and abolished by vagotomy. The inhibition of sympathetic activity was equally pronounced in the cardiac and renal nerves. After coronary artery occlusion and aortic obstruction, inhibition occurred as soon as the ventricular diastolic pressure had risen about 2 mmHg. In spinal animals both stimuli caused a sympathetic activation which was mainly restricted to the cardiac nerve. This activation is not due to mechanical changes, but rather a direct result of myocardial ischaemia. Coronary artery occlusion is able to produce both inhibition and activation of sympathetic fibres, but the activation is normally suppressed and thus seems not to be particularly important for circulatory control.