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Preparation, characterization, and stability of new prostaglandin E2 gel for local administration
A new gel delivery system for the local application of prostaglandin E2 consists of drug incorporated in the matrix of a cross-linked starch polymer. The properties of the starch powder provide a stabilizing milieu for the labile prostaglandin E2 and, by addition of saline, a ready-to-use gel for im...
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| Published in: | Journal of pharmaceutical sciences 1980-11, Vol.69 (11), p.1271-1273 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4270-82d4ea5f0489b9a0c056d14a49ded85972f30d71f9cabaf3fa995f6258746af53 |
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| cites | cdi_FETCH-LOGICAL-c4270-82d4ea5f0489b9a0c056d14a49ded85972f30d71f9cabaf3fa995f6258746af53 |
| container_end_page | 1273 |
| container_issue | 11 |
| container_start_page | 1271 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 69 |
| creator | Harris, A.S. Kirstein-Pedersen, A. Stenberg, P. Ulmsten, U. Wingerup, L. |
| description | A new gel delivery system for the local application of prostaglandin E2 consists of drug incorporated in the matrix of a cross-linked starch polymer. The properties of the starch powder provide a stabilizing milieu for the labile prostaglandin E2 and, by addition of saline, a ready-to-use gel for immediate local administration. The gel offers advantages over existing preparations in terms of chemical and microbiological stability, homogeneity, and dosage safety. This report outlines the pharmaceutical aspects involved in the development of the delivery system. |
| doi_str_mv | 10.1002/jps.2600691110 |
| format | article |
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The properties of the starch powder provide a stabilizing milieu for the labile prostaglandin E2 and, by addition of saline, a ready-to-use gel for immediate local administration. The gel offers advantages over existing preparations in terms of chemical and microbiological stability, homogeneity, and dosage safety. 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Pharm. Sci</addtitle><description>A new gel delivery system for the local application of prostaglandin E2 consists of drug incorporated in the matrix of a cross-linked starch polymer. The properties of the starch powder provide a stabilizing milieu for the labile prostaglandin E2 and, by addition of saline, a ready-to-use gel for immediate local administration. The gel offers advantages over existing preparations in terms of chemical and microbiological stability, homogeneity, and dosage safety. This report outlines the pharmaceutical aspects involved in the development of the delivery system.</description><subject>Administration, Topical</subject><subject>and stability</subject><subject>and stability of gel delivery system</subject><subject>characterization</subject><subject>Drug Contamination</subject><subject>Drug delivery systems-prostaglandin E2 gel</subject><subject>Drug delivery systems—prostaglandin E2 gel, preparation, characterization, and stability</subject><subject>Drug Stability</subject><subject>Gels</subject><subject>preparation</subject><subject>Prostaglandin E2-preparation</subject><subject>Prostaglandin E2—preparation, characterization, and stability of gel delivery system</subject><subject>Prostaglandins E - administration & dosage</subject><subject>Prostaglandins E - standards</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><recordid>eNqFkL1vFDEQxS0ECkegpUNyRcUettcf6xKifBAiiAQopTVnj4PD3u5h7xGOvx5HewqiQFS25r15M_Mj5DlnS86YeH2zKUuhGdOWc84ekAVXgjWacfOQLKpBNK2S9jF5UsoNqzam1AE5MFIJqdSCwGXGDWSY0ji8ov5r_foJc_q1r8AQaJlglfo07egY6YC3dJPHWrvuq5gGeizoNfY0jpn2o4eeQlinIZVpTn1KHkXoCz7bv4fky8nx56Oz5uLj6bujNxeNl8KwphNBIqjIZGdXFphnSgcuQdqAoVPWiNiyYHi0HlYQ2wjWqqiF6ozUEFV7SF7OuXW771ssk1un4rGvW-K4Lc6o1jKpu2pczkZfzygZo9vktIa8c5y5O6auMnV_mNaGF_vk7WqN4d6-h1h1O-u3qcfdf9Lc-eWnv7Kbubfywp_3vZC_OW1ao9zVh1N3df7-7YnSZ-5uVjf7saL8kTC74hMOHkPK6CcXxvSvM34DdDulkw</recordid><startdate>198011</startdate><enddate>198011</enddate><creator>Harris, A.S.</creator><creator>Kirstein-Pedersen, A.</creator><creator>Stenberg, P.</creator><creator>Ulmsten, U.</creator><creator>Wingerup, L.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198011</creationdate><title>Preparation, characterization, and stability of new prostaglandin E2 gel for local administration</title><author>Harris, A.S. ; Kirstein-Pedersen, A. ; Stenberg, P. ; Ulmsten, U. ; Wingerup, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4270-82d4ea5f0489b9a0c056d14a49ded85972f30d71f9cabaf3fa995f6258746af53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Administration, Topical</topic><topic>and stability</topic><topic>and stability of gel delivery system</topic><topic>characterization</topic><topic>Drug Contamination</topic><topic>Drug delivery systems-prostaglandin E2 gel</topic><topic>Drug delivery systems—prostaglandin E2 gel, preparation, characterization, and stability</topic><topic>Drug Stability</topic><topic>Gels</topic><topic>preparation</topic><topic>Prostaglandin E2-preparation</topic><topic>Prostaglandin E2—preparation, characterization, and stability of gel delivery system</topic><topic>Prostaglandins E - administration & dosage</topic><topic>Prostaglandins E - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, A.S.</creatorcontrib><creatorcontrib>Kirstein-Pedersen, A.</creatorcontrib><creatorcontrib>Stenberg, P.</creatorcontrib><creatorcontrib>Ulmsten, U.</creatorcontrib><creatorcontrib>Wingerup, L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, A.S.</au><au>Kirstein-Pedersen, A.</au><au>Stenberg, P.</au><au>Ulmsten, U.</au><au>Wingerup, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation, characterization, and stability of new prostaglandin E2 gel for local administration</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1980-11</date><risdate>1980</risdate><volume>69</volume><issue>11</issue><spage>1271</spage><epage>1273</epage><pages>1271-1273</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A new gel delivery system for the local application of prostaglandin E2 consists of drug incorporated in the matrix of a cross-linked starch polymer. The properties of the starch powder provide a stabilizing milieu for the labile prostaglandin E2 and, by addition of saline, a ready-to-use gel for immediate local administration. The gel offers advantages over existing preparations in terms of chemical and microbiological stability, homogeneity, and dosage safety. This report outlines the pharmaceutical aspects involved in the development of the delivery system.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7452455</pmid><doi>10.1002/jps.2600691110</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1980-11, Vol.69 (11), p.1271-1273 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75390468 |
| source | Wiley Online Library All Journals |
| subjects | Administration, Topical and stability and stability of gel delivery system characterization Drug Contamination Drug delivery systems-prostaglandin E2 gel Drug delivery systems—prostaglandin E2 gel, preparation, characterization, and stability Drug Stability Gels preparation Prostaglandin E2-preparation Prostaglandin E2—preparation, characterization, and stability of gel delivery system Prostaglandins E - administration & dosage Prostaglandins E - standards |
| title | Preparation, characterization, and stability of new prostaglandin E2 gel for local administration |
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