Long-term deterioration of quality of life in adult patients with celiac disease is associated with treatment noncompliance

• Published in: Digestive and liver disease 2010-10, Vol.42 (10), p.685-691
• Main Authors: Nachman, Fabio, del Campo, Marcela Planzer, González, Andrea, Corzo, Laura, Vázquez, Horacio, Sfoggia, Cristina, Smecuol, Edgardo, Sánchez, María Inés Pinto, Niveloni, Sonia, Sugai, Emilia, Mauriño, Eduardo, Bai, Julio C
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Celiac disease; Celiac Disease - diet therapy; Celiac Disease - psychology; Diet, Gluten-Free; Disease Progression; Female; Follow-Up Studies; Gastroenterology and Hepatology; Gluten-free diet; Humans; Male; Middle Aged; Outcome research; Patient Compliance; Prospective Studies; Quality of Life; Serology; Time Factors; Young Adult
• ISSN: 1590-8658; 1878-3562
• DOI: 10.1016/j.dld.2010.03.004

Abstract Background Deterioration of quality of life in the long term has been suggested for celiac disease patients on a gluten-free diet. Aims To determine long-term quality of life of celiac disease patients and to assess the benefits of gluten-free diet compliance. Patients We prospectively evaluated 53 newly diagnosed adult celiac disease patients. Methods The Short Form 36 Health Survey, the Gastrointestinal Symptoms Rating Scale and the Beck Depression Inventory were employed at the time of diagnosis, 1 year, and beyond 4 years (median: 53 months) on treatment. Results At 1 year, a significant improvement from baseline in quality of life indicators was observed ( p < 0.001 to p < 0.0001) with comparable scores to healthy subjects. At 4 years, the Short Form 36 Health Survey scores ( p < 0.002 to p < 0.0002) and Beck Depression Inventory score ( p < 0.002) show significant deterioration compare with 1 year. Most scores remained significantly better than those at diagnosis ( p < 0.03 to p < 0.0005). No changes were detected in the Gastrointestinal Symptoms Rating Scale scores. The long-term impairment of quality of life was attributable to the deterioration of most dimensions in patients who were not strictly compliant with the gluten-free diet ( p < 0.05 to p < 0.001). Conclusions Long-term deterioration of quality of life outcomes after the first year of gluten-free diet was associated with the lack of strict compliance with the diet.