Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells

Abstract Baicalein is a widely used Chinese herbal medicine that has been used historically in anti-inflammatory and anti-cancer therapy. However, the molecular mechanism of its anti-cancer activity remains poorly understood and warrants further investigations. The purpose of this study is to verify...

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Bibliographic Details
Published in:Cancer letters 2010-11, Vol.297 (1), p.42-48
Main Authors: Wang, Ling, Ling, Yun, Chen, Yan, Li, Cheng-Ling, Feng, Feng, You, Qi-Dong, Lu, Na, Guo, Qing-Long
Format: Article
Language:English
Subjects:
Adhesion
Antineoplastic Agents, Phytogenic - pharmacology
Baicalein
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - secondary
Cell adhesion & migration
Cell Adhesion - drug effects
Cell culture
Cell growth
Cell Line, Tumor
Cell Movement - drug effects
Dose-Response Relationship, Drug
Female
Fibronectins - metabolism
Flavanones - pharmacology
Hematology, Oncology and Palliative Medicine
Humans
Invasion
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Migration
Mitogen-Activated Protein Kinases - metabolism
MMP-2
MMP-9
Neoplasm Invasiveness
Signal Transduction - drug effects
Studies
Time Factors
Wound healing
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Summary:Abstract Baicalein is a widely used Chinese herbal medicine that has been used historically in anti-inflammatory and anti-cancer therapy. However, the molecular mechanism of its anti-cancer activity remains poorly understood and warrants further investigations. The purpose of this study is to verify the activity of baicalein to inhibit the invasion of MDA-MB-231 human breast cancer cells. The results indicated that baicalein suppressed MDA-MB-231 cell adhesion to fibronectin-coated substrate, wound healing migration and invasion through the Matrigel in a concentration-dependent manner. Western blot and gelatin zymography analysis showed that baicalein significantly inhibited the expression and secretion of matrix metalloproteinases 2/9 (MMP-2/9) in MDA-MB-231 cells. Additionally, treatment of MDA-MB-231 cells with baicalein down-regulated the expression of MMP-2/9 involved mitogen-activated protein kinases (MAPK) signaling pathway. Taken together, baicalein had potential to suppress the adhesion, migration and invasion of MDA-MB-231 cancer cells in vitro and it could serve as a promising drug for the treatment of cancer metastasis.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2010.04.022