Rosiglitazone reverses cardiac adverse remodeling (fibrosis and vascularization) in perinatal low protein rat offspring

Rosiglitazone, a PPAR gamma agonist, is an antidiabetic drug that shows secondary beneficial actions on cardiovascular system. Our study is centered on myocardial remodeling in maternal protein restriction offspring, focusing on fibrosis and vascularization. Wistar rat dams received one of the two d...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2010-09, Vol.206 (9), p.642-646
Main Authors: Torres, Thiago da Silva, Aguila, Marcia Barbosa, Mandarim-de-Lacerda, Carlos Alberto
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - drug effects
Cardiac remodeling
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - etiology
Cardiovascular Diseases - pathology
Diet, Protein-Restricted - adverse effects
Fibrosis
Heart - drug effects
Hypertension
Hypoglycemic Agents - pharmacology
Low protein diet
Male
PPAR gamma - agonists
Rats
Rats, Wistar
Rosiglitazone
Thiazolidinediones - pharmacology
Ventricular Remodeling - drug effects
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Summary:Rosiglitazone, a PPAR gamma agonist, is an antidiabetic drug that shows secondary beneficial actions on cardiovascular system. Our study is centered on myocardial remodeling in maternal protein restriction offspring, focusing on fibrosis and vascularization. Wistar rat dams received one of the two diets: normal (19% protein; NP) or low protein (5% protein; LP) during gestation and lactation. Three-month-old male offspring were divided into four groups: NP treated with rosiglitazone (NPR, 5 mg/kg/day); untreated NP (NP); LP treated (LPR); untreated LP (LP) until six months. Blood pressure (BP) was higher in LP, but rosiglitazone reduced BP at the first week of treatment in LPR. Rosiglitazone had beneficial effects on fibrosis (less than 23%, P < 0.05) and vascularization (plus 57% of capillary/cardiomyocyte ratio, P < 0.01) compared with LP offspring, independently of blood glucose. Multivariate analysis classified 95% of groups, and LPR offspring showed values close to those of NP offspring. Rosiglitazone showed beneficial effects on rat offspring programmed by low protein diet during gestation decreasing cardiac fibrosis and enhancing myocardial vascularization. These results are significant in translational medicine for patients with chronic diseases in adult life and increased cardiovascular risk.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2010.03.007