Energy expenditure and impact of bronchodilators in COPD patients

• Published in: Respiratory medicine 2010-10, Vol.104 (10), p.1490-1494
• Main Authors: Cazzola, Mario, Segreti, Andrea, Stirpe, Emanuele, Appodia, Massimiliano, Senis, Lucia, Matera, Maria G
• Format: Article
• Language: English
• Subjects: Accelerometers; Airway management; Biological and medical sciences; Bronchodilator Agents - therapeutic use; Bronchodilators; Chronic obstructive pulmonary disease, asthma; COPD; Drug Therapy, Combination; Energy expenditure; Energy Metabolism - drug effects; Energy Metabolism - physiology; Ethanolamines - therapeutic use; Exercise Test - methods; Exercise Tolerance - drug effects; Exercise Tolerance - physiology; Female; Forced Expiratory Volume - drug effects; Formoterol Fumarate; Humans; Male; Medical sciences; Middle Aged; Physical fitness; Pneumology; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary/Respiratory; Scopolamine Derivatives - therapeutic use; SenseWear ® Armband; Spirometry; Studies; Tiotropium Bromide; Treatment Outcome; Walking; Walking - physiology
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2010.04.002

Summary 28 Consecutive COPD patients performed four 6-minute walking tests (6-MWTs) in 2 different days before and 2, 4 and 6 h after the inhalation of formoterol 12 μg or tiotropium 18 μg, respectively. Physical activity during each 6-MWT was assessed by the SenseWear® Armband. At each time also spirometry was performed. Both formoterol and tiotropium induced a significantly sustained bronchodilation and influenced hyperinflation. Formoterol significantly increased distance walked in 6 min at 2 h and at 4 h, whereas tiotropium significantly increased it at all time points. There was a trend to an increase in calories and metabolic equivalents of task (METs) after formoterol and a decrease after tiotropium, but changes were not statistically significant. Total energy expenditure for each 6-MWT was not changed by formoterol, but decreased in significant manner 6 h after the inhalation of tiotropium. Active energy expenditure at physical activity level of more than 3 METs decreased significantly after tiotropium at each 6-MWT, but not after formoterol. We did not find any significant correlation between the changes in lung function and those of parameters recorded with SenseWear® Armband. Our study seems to indicate that tiotropium, but not formoterol, is able to reduce energy expenditure in COPD patients, although both drugs elicit significant bronchodilation and are able to increase the distance walked in 6 min.