Evaluation of Safety and Immunotoxicity of Immunol, A Polyherbal Formulation in Rats

Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg super(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg super(-1) b.wt., orally for 28 days. Immunol treatment did not...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmacology & toxicology 2010-10, Vol.5 (6), p.262-274
Main Authors: Sulaiman, S.M., Rajashekha, Geetha, Prakash, P.J., Singh, D.S., Saleem, C.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg super(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg super(-1) b.wt., orally for 28 days. Immunol treatment did not elicit any abnormalities on the body weight gain, food consumption, neurological assessment, hematology and clinical chemistry parameters, organ weights, gross organ pathology and histopathology and humoral immunity, but it enhanced the cell mediated immunity. It was concluded that Immunol was safe at single oral dose of 20 mL kg super(-1) b.wt. and repeated dose of 10 mL kg super(-1) b.wt. in rats for 28 days.
ISSN:1816-496X
DOI:10.3923/jpt.2010.262.274