Rhythm-Promoting Actions of Exercise in Mice with Deficient Neuropeptide Signaling

Daily exercise promotes physical health as well as improvements in mental and neural functions. Studies in intact wild-type (WT) rodents have revealed that the brain's suprachiasmatic nuclei (SCN), site of the main circadian pacemaker, are also responsive to scheduled wheel running. It is uncle...

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Bibliographic Details
Published in:Journal of biological rhythms 2010-08, Vol.25 (4), p.235-246
Main Authors: Power, A, Hughes, A.T.L, Samuels, R.E, Piggins, H.D
Format: Article
Language:English
Subjects:
Animals
Brain
Circadian rhythm
Circadian Rhythm - genetics
Circadian Rhythm - physiology
Circadian rhythms
Darkness
Etiology
Intervention
Intestine
Mice
Motor Activity - physiology
Nuclei
Periodicity
Physical training
Proto-Oncogene Proteins c-fos - biosynthesis
Receptors, Vasoactive Intestinal Peptide, Type II - deficiency
Rhythm
Rodents
Suprachiasmatic Nucleus - physiology
Vasoactive agents
Vasoactive intestinal peptide
Vasoactive Intestinal Peptide - deficiency
Wheel running
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Summary:Daily exercise promotes physical health as well as improvements in mental and neural functions. Studies in intact wild-type (WT) rodents have revealed that the brain's suprachiasmatic nuclei (SCN), site of the main circadian pacemaker, are also responsive to scheduled wheel running. It is unclear, however, if and how animals with a dysfunctional circadian pacemaker respond to exercise. Here, we tested whether scheduled voluntary exercise (SVE) in a running wheel for 6 hours per day could promote neural and behavioral rhythmicity in animals whose circadian competence is compromised through genetically targeted loss of vasoactive intestinal polypeptide (VIP⁻/⁻ mice) or its VPAC₂ receptor (Vipr2⁻/⁻ mice). We report that in constant dark (DD), rhythmic VIP⁻/⁻ and Vipr2⁻/⁻ mice show weak free-running rhythms with a period of
ISSN:0748-7304
1552-4531
DOI:10.1177/0748730410374446