Impact of belief in neuroprotection on therapeutic intervention in Parkinson's disease

We explored the hypotheses that an investigator's belief in a putative neuroprotective agent might influence the timing of symptomatic intervention and the assessment of signs and symptoms of patients with Parkinson's disease with the Unified Parkinson's Disease Rating Scale (UPDRS)....

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Bibliographic Details
Published in:Movement disorders 2010-06, Vol.25 (8), p.1082-1086
Main Authors: Elble, Rodger J., Suchowersky, Oksana, Shaftman, Stephanie, Weiner, William J., Huang, Peng, Tilley, Barbara
Format: Article
Language:English
Subjects:
Adult
Aged
bias
Biological and medical sciences
clinical trial
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Male
Medical sciences
Middle Aged
Neurology
Neuroprotective Agents - therapeutic use
Parkinson Disease - drug therapy
Parkinson Disease - psychology
Parkinson's disease
Randomized Controlled Trials as Topic
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome
Ubiquinone - therapeutic use
Unified Parkinson's Disease Rating Scale
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Summary:We explored the hypotheses that an investigator's belief in a putative neuroprotective agent might influence the timing of symptomatic intervention and the assessment of signs and symptoms of patients with Parkinson's disease with the Unified Parkinson's Disease Rating Scale (UPDRS). These hypotheses were tested with Cox and general linear modeling, using data from a previously published double‐blind placebo‐controlled futility trial of coenzyme Q10 and GPI‐1485. We found the investigators' level of confidence in these agents had no effect on the time to symptomatic therapy or on the change in UPDRS during 12 months of treatment. © 2010 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.22997