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Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial
Aim Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence. Method A randomized controlled study was carried out including 261...
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| Published in: | Colorectal disease 2010-08, Vol.12 (8), p.799-803 |
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| cites | cdi_FETCH-LOGICAL-c4390-416f4fec531a4fea3abefd94e053eca14516009693385799680ea9969d0dabcc3 |
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| container_title | Colorectal disease |
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| creator | Mistrangelo, M. Cornaglia, S. Pizzio, M. Rimonda, R. Gavello, G. Dal Conte, I. Mussa, A. |
| description | Aim Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence.
Method A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent.
Results The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P |
| doi_str_mv | 10.1111/j.1463-1318.2009.01960.x |
| format | article |
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Method A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent.
Results The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P < 0.0001). There were no significant differences in the sex, sexual orientation, number of lesions, time to diagnosis and treatment or localization of lesions in the two groups.
Conclusions Immunostimulation using a natural product significantly reduced the incidence of recurrence of anal condylomata in patients undergoing surgical excision.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/j.1463-1318.2009.01960.x</identifier><identifier>PMID: 19548899</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adjuvants, Immunologic - therapeutic use ; Adolescent ; Adult ; Andrographis ; Anogenital warts ; Anus Diseases - surgery ; Anus Diseases - therapy ; Anus Diseases - virology ; Carica ; Child ; Citrus paradisi ; condylomata acuminata ; Condylomata Acuminata - surgery ; Condylomata Acuminata - therapy ; current therapies ; Echinacea ; Female ; Human immunodeficiency virus ; Human papillomavirus ; Humans ; immunomodulation ; Male ; Middle Aged ; natural therapies ; Phytotherapy - methods ; Plant Preparations - therapeutic use ; Prospective Studies ; recurrences ; Secondary Prevention ; Statistics, Nonparametric ; Tabebuia ; Uncaria ; Young Adult</subject><ispartof>Colorectal disease, 2010-08, Vol.12 (8), p.799-803</ispartof><rights>2010 The Authors. Journal Compilation © 2010 The Association of Coloproctology of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4390-416f4fec531a4fea3abefd94e053eca14516009693385799680ea9969d0dabcc3</citedby><cites>FETCH-LOGICAL-c4390-416f4fec531a4fea3abefd94e053eca14516009693385799680ea9969d0dabcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19548899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mistrangelo, M.</creatorcontrib><creatorcontrib>Cornaglia, S.</creatorcontrib><creatorcontrib>Pizzio, M.</creatorcontrib><creatorcontrib>Rimonda, R.</creatorcontrib><creatorcontrib>Gavello, G.</creatorcontrib><creatorcontrib>Dal Conte, I.</creatorcontrib><creatorcontrib>Mussa, A.</creatorcontrib><title>Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Aim Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence.
Method A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent.
Results The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P < 0.0001). There were no significant differences in the sex, sexual orientation, number of lesions, time to diagnosis and treatment or localization of lesions in the two groups.
Conclusions Immunostimulation using a natural product significantly reduced the incidence of recurrence of anal condylomata in patients undergoing surgical excision.</description><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Andrographis</subject><subject>Anogenital warts</subject><subject>Anus Diseases - surgery</subject><subject>Anus Diseases - therapy</subject><subject>Anus Diseases - virology</subject><subject>Carica</subject><subject>Child</subject><subject>Citrus paradisi</subject><subject>condylomata acuminata</subject><subject>Condylomata Acuminata - surgery</subject><subject>Condylomata Acuminata - therapy</subject><subject>current therapies</subject><subject>Echinacea</subject><subject>Female</subject><subject>Human immunodeficiency virus</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>immunomodulation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>natural therapies</subject><subject>Phytotherapy - methods</subject><subject>Plant Preparations - therapeutic use</subject><subject>Prospective Studies</subject><subject>recurrences</subject><subject>Secondary Prevention</subject><subject>Statistics, Nonparametric</subject><subject>Tabebuia</subject><subject>Uncaria</subject><subject>Young Adult</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhSMEoqXwCsg7VhnsceLYLJAghTKlohtQl9Yd5wZ5cOLBdmCm6sPjdEZlCd6cI_nczz-nKAijC5bX682CVYKXjDO5WFKqFpQpQRe7R8Xpw8bje78spWL0pHgW44ZSJhomnxYnTNWVlEqdFnerYZhGH5MdJgfJ-pEkTwJ2k8EsZgoBx2yhTxhInMJ3DHvS-0BgBEeMH7u98wMQMNNgR0jwhgDZBh-3aJL9lSEwdn6wt9jN6RS8c9mmYME9L5704CK-OOpZ8e3jh6_tp_Lq-mLVvrsqTcUVLSsm-qpHU3MGWYHDGvtOVUhrjgZYVTORP0EozmXdKCUkRciiOtrB2hh-Vrw6cPO9fk4Ykx5sNOgcjOinqJu6qmsp6PLfSV5RKngjc1Iekia_NQbs9TbYAcJeM6rnkvRGz13ouQs9l6TvS9K7PPryeMi0HrD7O3hsJQfeHgK_rcP9f4N1e32-mm0GlAeAjQl3DwAIP7RoeFPrmy8XWrbv1eeby0vd8j9hYrKX</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Mistrangelo, M.</creator><creator>Cornaglia, S.</creator><creator>Pizzio, M.</creator><creator>Rimonda, R.</creator><creator>Gavello, G.</creator><creator>Dal Conte, I.</creator><creator>Mussa, A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201008</creationdate><title>Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial</title><author>Mistrangelo, M. ; Cornaglia, S. ; Pizzio, M. ; Rimonda, R. ; Gavello, G. ; Dal Conte, I. ; Mussa, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4390-416f4fec531a4fea3abefd94e053eca14516009693385799680ea9969d0dabcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Andrographis</topic><topic>Anogenital warts</topic><topic>Anus Diseases - surgery</topic><topic>Anus Diseases - therapy</topic><topic>Anus Diseases - virology</topic><topic>Carica</topic><topic>Child</topic><topic>Citrus paradisi</topic><topic>condylomata acuminata</topic><topic>Condylomata Acuminata - surgery</topic><topic>Condylomata Acuminata - therapy</topic><topic>current therapies</topic><topic>Echinacea</topic><topic>Female</topic><topic>Human immunodeficiency virus</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>immunomodulation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>natural therapies</topic><topic>Phytotherapy - methods</topic><topic>Plant Preparations - therapeutic use</topic><topic>Prospective Studies</topic><topic>recurrences</topic><topic>Secondary Prevention</topic><topic>Statistics, Nonparametric</topic><topic>Tabebuia</topic><topic>Uncaria</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mistrangelo, M.</creatorcontrib><creatorcontrib>Cornaglia, S.</creatorcontrib><creatorcontrib>Pizzio, M.</creatorcontrib><creatorcontrib>Rimonda, R.</creatorcontrib><creatorcontrib>Gavello, G.</creatorcontrib><creatorcontrib>Dal Conte, I.</creatorcontrib><creatorcontrib>Mussa, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mistrangelo, M.</au><au>Cornaglia, S.</au><au>Pizzio, M.</au><au>Rimonda, R.</au><au>Gavello, G.</au><au>Dal Conte, I.</au><au>Mussa, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2010-08</date><risdate>2010</risdate><volume>12</volume><issue>8</issue><spage>799</spage><epage>803</epage><pages>799-803</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence.
Method A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent.
Results The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P < 0.0001). There were no significant differences in the sex, sexual orientation, number of lesions, time to diagnosis and treatment or localization of lesions in the two groups.
Conclusions Immunostimulation using a natural product significantly reduced the incidence of recurrence of anal condylomata in patients undergoing surgical excision.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19548899</pmid><doi>10.1111/j.1463-1318.2009.01960.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - therapeutic use Adolescent Adult Andrographis Anogenital warts Anus Diseases - surgery Anus Diseases - therapy Anus Diseases - virology Carica Child Citrus paradisi condylomata acuminata Condylomata Acuminata - surgery Condylomata Acuminata - therapy current therapies Echinacea Female Human immunodeficiency virus Human papillomavirus Humans immunomodulation Male Middle Aged natural therapies Phytotherapy - methods Plant Preparations - therapeutic use Prospective Studies recurrences Secondary Prevention Statistics, Nonparametric Tabebuia Uncaria Young Adult |
| title | Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial |
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