Impact of hepatitis B virus infection on outcome following resection for intrahepatic cholangiocarcinoma

Background Little is known about the prognosis of intrahepatic cholangiocarcinoma (ICC) patients with hepatitis B virus (HBV) infection following surgical resection. Methods The clinico‐pathological data of 40 consecutive ICC patients including 29 patients with HBV infection were analyzed after surg...

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Published in:Journal of surgical oncology 2010-03, Vol.101 (3), p.233-238
Main Authors: Zhang, Lei, Cai, Jian-Qiang, Zhao, Jian-Jun, Bi, Xin-Yu, Tan, Xiao-Gang, Yan, Tao, Li, Cong, Zhao, Ping
Format: Article
Language:English
Subjects:
Adult
Aged
Bile Duct Neoplasms - mortality
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Bile Ducts, Intrahepatic
Cholangiocarcinoma - mortality
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Female
Hepatitis B - immunology
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Hepatitis B virus
Humans
intrahepatic cholangiocarcinoma
Lymphatic Metastasis
Male
Middle Aged
surgical resection
survival
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Summary:Background Little is known about the prognosis of intrahepatic cholangiocarcinoma (ICC) patients with hepatitis B virus (HBV) infection following surgical resection. Methods The clinico‐pathological data of 40 consecutive ICC patients including 29 patients with HBV infection were analyzed after surgical resection. Results Of all 40 ICC patients, the overall 1‐, 3‐, 5‐year survival rates and a median survival for 29 (74.4%) patients with current or previous HBV infection were 78.9%, 42.8%, 35.7%, and 32.0 months, respectively. Twenty‐nine (74.4%) patients with HBV infection, represented by HBsAg+ or anti‐HBc+, had a better prognosis than 10(25%) patients without HBV infection represented by all markers‐negative. Compared with 10 (25%) patients without HBV infection, 11 (27.5%) ICC patients with HBsAg+ had a better prognosis as well. Additionally, lymph node metastasis were identified as an independent predictors of poor overall survival on multivariate analysis in the study of all the 40 patients and 29 patients with HBV infection. Conclusions Patients with current or previous HBV infection, represented by HBsAg+ or anti‐HBc+, had significantly better prognosis than patients without HBV infection. Patients with HBV infection should be distinguished from other ICC patients, because of their favorable outcome after surgery. J. Surg. Oncol. 2010; 101:233–238. © 2010 Wiley‐Liss, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.21488