Risk of immune hemolytic anemia in children following immunization

Abstract Several case reports have described immune hemolytic anemia (IHA) following vaccination in children. We examined the risk of IHA in the 42 days following vaccination exposure using a self-controlled case series study design. In our population-based cohort of nearly 4.5 million children in t...

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Bibliographic Details
Published in:Vaccine 2009-12, Vol.27 (52), p.7394-7397
Main Authors: Naleway, Allison L, Belongia, Edward A, Donahue, James G, Kieke, Burney A, Glanz, Jason M
Format: Article
Language:English
Subjects:
Adolescent
Allergy and Immunology
Anemia
Anemia, Hemolytic - chemically induced
Anemia, Hemolytic - epidemiology
Antigens
Applied microbiology
Back pain
Biological and medical sciences
Blood
Blood diseases
Case reports
Child
Child, Preschool
Cohort Studies
Comorbidity
Diphtheria-Tetanus-Pertussis Vaccine - adverse effects
Female
Fundamental and applied biological sciences. Psychology
Health insurance
Hemolysis
Hemolytic anemia
Hepatitis
Hepatitis B Vaccines - adverse effects
Humans
Immunization
Incidence
Infant
Male
Medical records
Microbiology
Pediatrics
Population
Public access
Public health
Risk
Tetanus
United States - epidemiology
Vaccination - adverse effects
Vaccine safety
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Whooping cough
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Summary:Abstract Several case reports have described immune hemolytic anemia (IHA) following vaccination in children. We examined the risk of IHA in the 42 days following vaccination exposure using a self-controlled case series study design. In our population-based cohort of nearly 4.5 million children in the Vaccine Safety Datalink, we identified 55 confirmed cases of new-onset IHA from 1991 through 2000. We found no association between IHA and diphtheria–pertussis–tetanus vaccination (incidence rate ratio (IRR) = 0.65, 95% CI: 0.19–2.24), hepatitis B vaccination (IRR = 1.73, 95% CI: 0.59–5.01), or any vaccination (IRR = 1.04, 95% CI: 0.46–2.32).
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.09.023