Comparison of High Risk Stress Myocardial Perfusion Imaging Findings in Men With Rapid Versus Prolonged Recovery of ST-Segment Depression After Exercise Stress Testing

ST-segment depression during stress testing predicts future risk for adverse cardiovascular events and routinely prompts further noninvasive imaging or invasive evaluation for coronary artery disease (CAD). A subset of patients develop ST depression at peak exercise that rapidly resolves early in th...

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Bibliographic Details
Published in:The American journal of cardiology 2010-05, Vol.105 (10), p.1361-1364
Main Authors: Rich, Jonathan D., MD, Chen, Stuart, MD, Ward, R. Parker, MD
Format: Article
Language:English
Subjects:
Age Distribution
Aged
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiorespiratory
Cardiovascular
Cardiovascular disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - epidemiology
Databases, Factual
Electrocardiography
Exercise
Exercise Test - methods
Heart Rate - physiology
Humans
Incidence
Male
Medical imaging
Medical sciences
Men
Middle Aged
Myocardial Perfusion Imaging - methods
Physical Exertion - physiology
Predictive Value of Tests
Prognosis
Prospective Studies
Recovery of Function
Reference Values
Risk Assessment
Time Factors
Tomography, Emission-Computed, Single-Photon - methods
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Description
Summary:ST-segment depression during stress testing predicts future risk for adverse cardiovascular events and routinely prompts further noninvasive imaging or invasive evaluation for coronary artery disease (CAD). A subset of patients develop ST depression at peak exercise that rapidly resolves early in the recovery period (ST-rapid). The goal of this study was to compare the prevalence of single-photon emission computed tomographic myocardial perfusion imaging (MPI) findings in patients with ST-rapid to those with prolonged ST depression (ST-prolonged) and those without ST depression (ST-normal). A total of 637 men without previous CAD and with interpretable rest electrocardiograms referred for exercise stress MPI were included in this study. ST depression was defined as ≥1-mm ST depression occurring 80 ms after the J point at peak exercise. ST-rapid was defined as ST depression with recovery of the ST depression by 1 minute into recovery. Men with ST-rapid were younger (55.4 ± 7.6 vs 62.6 ± 9.6 years, p 8 or ejection fraction
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2009.12.061