Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes

• Published in: Talanta (Oxford) 2010-06, Vol.82 (1), p.286-295
• Main Authors: Kul, Dilek, Gumustas, Mehmet, Uslu, Bengi, Ozkan, Sibel A.
• Format: Article
• Language: English
• Subjects: Analytical chemistry; Antipsychotic Agents - analysis; Antipsychotic Agents - blood; Antipsychotic Agents - chemistry; Antipsychotic Agents - isolation & purification; Boron - chemistry; Boron-doped diamond electrode; Centrifugation; Chemical Precipitation; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography, Liquid; Diamond - chemistry; Electrochemical methods; Electrochemistry; Electrodes; Exact sciences and technology; Glass - chemistry; Glassy carbon electrode; Humans; Other chromatographic methods; Oxidation-Reduction; Pharmaceutical Preparations - chemistry; Pharmaceuticals; Piperazines - analysis; Piperazines - blood; Piperazines - chemistry; Piperazines - isolation & purification; Reproducibility of Results; Thiazoles - analysis; Thiazoles - blood; Thiazoles - chemistry; Thiazoles - isolation & purification; Time Factors; Voltammetry; Ziprasidone
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2010.04.036

Ziprasidone is a psychotropic agent used for the treatment of schizophrenia. Its oxidation was investigated electrochemically at boron-doped diamond and glassy carbon electrodes using cyclic, differential pulse, and square wave voltammetry. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate were examined. The process was diffusion and adsorption controlled for boron-doped diamond and glassy carbon electrodes, respectively. The possible mechanism of oxidation was discussed with some model compounds that have indole and piperazine oxidations. A linear response was obtained between 8 × 10 −7 and 8 × 10 −5 M for the first peak in acetate buffer (pH 5.5) and between 2 × 10 −6 and 2 × 10 −4 M for the second peak in 0.1 M H 2SO 4 with boron-doped diamond electrode for differential pulse and square wave voltammetric techniques. The reproducibility and accuracy of the proposed methods were found between 0.31 and 1.20, 99.27 and 100.22, respectively. The recovery studies were also achieved to check selectivity and accuracy of the methods. The proposed methods were applied for the determination of ziprasidone from pharmaceutical dosage forms and human serum samples without any time-consuming extraction, separation, evaporation or adsorption steps prior to drug assay except precipitation of the proteins using acetonitrile. The results were statistically compared with those obtained through an established LC–UV technique, no significant differences were been found between the voltammetric and LC methods.