Multi-variety bone bank in China

• Published in: Cell and tissue banking 2010-08, Vol.11 (3), p.233-240
• Main Authors: Li, Dan, Bi, Long, Meng, Guo-Lin, Liu, Min, Jin, Jing, Liu, Yin, Wang, Zhen, Liu, Jian, Hu, Yun-Yu
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Bone Banks - organization & administration; Bone marrow, stem cells transplantation. Graft versus host reaction; Bone Transplantation; Bones; Cell Biology; Child; China; Education, Professional; Hepatitis B virus; Hepatitis C virus; Human immunodeficiency virus; Humans; Life Sciences; Male; Medical sciences; Quality control; Skin & tissue grafts; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue engineering; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplant Surgery; Transplantation, Heterologous; Transplantation, Homologous
• ISSN: 1389-9333; 1573-6814
• DOI: 10.1007/s10561-009-9151-2

This is a descriptive report of the establishment and operation of a Chinese bone bank, though not a typical one. While being engaged in collection, processing and storage of allogeneic tissues, the bone bank to which the author belongs concurrently develops and produces new, non-human derived, graft materials. Among others is reconstituted bone xenograft (RBX) which possesses strong osteoinductive capability without evoking immune rejection. Hence, its appellation “multi-variety bone bank,” which was established by Dr. Hu Yunyu in 1990, the first of its kind in China. There are several salient features discriminating this bone bank from others. At this hospital-based non-profit institution, allograft hemi-joints are freshly prepared and distributed deep-frozen, instead of being freeze-dried on an industrialized basis for convenient transportation. The former has much more superior biological and mechanical properties as compared with the latter. However, allogeneic tissues are sometimes in short supply due to limited number of donors and the risk of some potential donors carrying viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). New graft materials, including reconstituted bone xenograft (RBX), were developed that serve as a supplement to allografts. RBX has been successfully used in clinical practice for the management of old fractures, nonunions and bone defects, most notably of contaminated, infected open fractures and osteomyelitis with the use of anti-infective reconstituted bone xenograft (ARBX). Additionally the multi-variety bone bank serves as a training base for educating professional personnel and researchers (postgraduates) in theories and technologies of tissue banking. Up to now, eighteen special technical staff members and approximately sixty senior researchers have been trained at this institution.