Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis

• Published in: Journal of antimicrobial chemotherapy 2010-08, Vol.65 (8), p.1749-1752
• Main Authors: Jacqueline, Cédric, Amador, Gilles, Caillon, Jocelyne, Le Mabecque, Virginie, Batard, Eric, Miègeville, Anne-Françoise, Biek, Donald, Ge, Yigong, Potel, Gilles, Hamel, Antoine
• Format: Article
• Language: English
• Subjects: Acetamides - therapeutic use; Animals; Anti-Bacterial Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial arthritis and osteitis; Bacterial diseases; Biological and medical sciences; bone; Bone and Bones - microbiology; Bone Marrow - microbiology; Ceftaroline; Cephalosporins - therapeutic use; Disease Models, Animal; Female; Human bacterial diseases; Infectious diseases; Linezolid; Medical sciences; Methicillin-Resistant Staphylococcus aureus - drug effects; MRSA; Osteomyelitis - drug therapy; Osteomyelitis - microbiology; Oxazolidinones - therapeutic use; Pharmacology. Drug treatments; Rabbits; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcal infections, streptococcal infections, pneumococcal infections; Staphylococcus aureus; Treatment Outcome; vancomycin; Vancomycin - therapeutic use
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkq193

Objectives To evaluate the activity of a new cephalosporin, ceftaroline, in comparison with other antistaphylococcal drugs (linezolid and vancomycin) at projected human therapeutic doses against methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide-intermediate S. aureus (GISA) strains. Methods Using a rabbit experimental model of acute osteomyelitis, efficacy was assessed following 4 days of treatment by colony counts of infected bone tissues (joint fluid, femoral bone marrow and bone). Results Although vancomycin remains the standard treatment for MRSA osteomyelitis, it was ineffective against the MRSA strain and poorly active against GISA infections in this model. Ceftaroline and linezolid demonstrated significant activity in bone marrow and bone, and were significantly better than vancomycin treatment. However, ceftaroline was the only drug to exhibit significant activity against MRSA in infected joint fluid. Conclusions The present study supports ceftaroline as a promising therapeutic option for the treatment of severe MRSA infections, including osteomyelitis.