Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects

• Published in: European journal of clinical nutrition 2008-11, Vol.62 (11), p.1287-1293
• Main Authors: Guebre-Egziabher, F, Rabasa-Lhoret, R, Bonnet, F, Bastard, J.P, Desage, M, Skilton, M.R, Vidal, H, Laville, M
• Format: Article
• Language: English
• Subjects: Adiponectin; Adiponectin - blood; Adult; alpha-linolenic acid; Basal Metabolism - drug effects; Basal Metabolism - physiology; Biological and medical sciences; Calorimetry; Calorimetry, Indirect; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - prevention & control; cardiovascular risk factors; Cholesterol; Clinical Nutrition; Composition; cytokines; Diet; Dietary intake; Energy expenditure; Epidemiology; Erythrocyte Membrane - chemistry; Erythrocytes; Fasting; Fatty acid composition; fatty acid oxidation; Fatty acids; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - blood; Fatty Acids, Omega-6 - administration & dosage; Fatty Acids, Omega-6 - blood; Feeding. Feeding behavior; Female; Food intake; Fundamental and applied biological sciences. Psychology; Glucose Clamp Technique; Health aspects; Health risks; Hormones; Humans; Inflammation; Inflammation - blood; Inflammation - epidemiology; Inflammation - prevention & control; Insulin; Insulin - blood; Internal Medicine; Intervention; Linoleic acid; Linolenic acid; Lipid peroxidation; Lipids; Lipids - blood; Male; Medical sciences; Medicine; Medicine & Public Health; Membranes; men; Metabolic Diseases; nutrient intake; Nutrition; nutritional intervention; omega-3 fatty acids; omega-6 fatty acids; original-article; Oxidation; Oxidation-Reduction; Patient Compliance; Physiological aspects; Polyunsaturated fatty acids; Public Health; resting energy expenditure; Risk analysis; Risk Factors; Tumor necrosis factor-α; Unsaturated fatty acids; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1602857

Background/Objectives: Consumption of n-3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low n-3 PUFA intake and an imbalance in the n-6/n-3 PUFA ratio. Study the effect 10-week of diet modification to decrease the n-6/n-3 PUFA ratio on cardiovascular risk factors and resting energy expenditure. Subjects and methods: Ten-week dietary intervention in 17 healthy subjects. Dietary intake, euglycemic hyperinsulinemic clamp, indirect calorimetry, lipid profile, hormones, inflammatory markers and erythrocyte membrane fatty acid composition were recorded before and at the end of the intervention. Comparisons are between baseline and post-treatment levels. Results: Dietary records of the linoleic acid/α-linolenic acid ratio (baseline: 32.2 (s.d. 3.7) vs post-intervention: 2.2 (s.d. 0.1), P