Synthesis and Characterization of an Injectable Allograft Bone/Polymer Composite Bone Void Filler with Tunable Mechanical Properties

In recent years, considerable effort has been expended toward the development of synthetic bone graft materials. Injectable biomaterials offer several advantages relative to implants due to their ability to cure in situ , thus conforming to irregularly shaped defects. While Food and Drug Administrat...

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Bibliographic Details
Published in:Tissue engineering. Part A 2010-08, Vol.16 (8), p.255-2518
Main Authors: Dumas, Jerald E., Zienkiewicz, Katarzyna, Tanner, Shaun A., Prieto, Edna M., Bhattacharyya, Subha, Guelcher, Scott A.
Format: Article
Language:English
Subjects:
Animals
Artificial bones
Biomedical materials
Bone Demineralization Technique - methods
Bone Substitutes - administration & dosage
Bone Substitutes - chemical synthesis
Bone Transplantation - methods
Bone-grafting
Bones
Femoral Fractures - pathology
Femoral Fractures - therapy
Injections
Materials Testing
Mechanical properties
Methods
Original Articles
Polymeric composites
Polymers
Polyurethanes - administration & dosage
Polyurethanes - chemical synthesis
Rats
Rats, Nude
Skin & tissue grafts
Technology application
Tissue engineering
Treatment Outcome
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Summary:In recent years, considerable effort has been expended toward the development of synthetic bone graft materials. Injectable biomaterials offer several advantages relative to implants due to their ability to cure in situ , thus conforming to irregularly shaped defects. While Food and Drug Administration–approved injectable calcium phosphate cements have excellent osteoconductivity and compressive strengths, these materials have small pore sizes (e.g., 1 μm) and are thus relatively impermeable to cellular infiltration. To overcome this limitation, we aimed to develop injectable allograft bone/polyurethane (PUR) composite bone void fillers with tunable properties that support rapid cellular infiltration and remodeling. The materials comprised particulated (e.g., >100 μm) allograft bone particles and a biodegradable two-component PUR, and had variable (e.g., 30%–70%) porosities. The injectable void fillers exhibited an initial dynamic viscosity of 220 Pa·s at clinically relevant shear rates (40 s −1 ), wet compressive strengths ranging from
ISSN:1937-3341
1937-335X
DOI:10.1089/ten.tea.2009.0672