Longitudinal analysis of radiographic trabecular pattern by image processing

To describe structural and textural changes in bone structure, the radiographic trabecular pattern of children, aged 4-14 years, was examined using a digital image processing system. This investigation is based on data from the Nijmegen Growth Study, a mixed-longitudinal growth study comprised of th...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 1995-12, Vol.17 (6), p.527-532
Main Authors: KORSTJENS, C. M, GERAETS, W. G. M, VAN GINKEL, F. C, PRAHL-ANDERSEN, B, VAN DER STELT, P. F, BURGER, E. H
Format: Article
Language:English
Subjects:
Adolescent
Analysis of Variance
Biological and medical sciences
Bone and Bones - diagnostic imaging
Bone Development
Child
Child, Preschool
Cohort Studies
Humans
Investigative techniques, diagnostic techniques (general aspects)
Longitudinal Studies
Medical sciences
Models, Biological
Osteoarticular system. Muscles
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiographic Image Enhancement
Reference Values
Reproducibility of Results
Statistics, Nonparametric
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Summary:To describe structural and textural changes in bone structure, the radiographic trabecular pattern of children, aged 4-14 years, was examined using a digital image processing system. This investigation is based on data from the Nijmegen Growth Study, a mixed-longitudinal growth study comprised of three birth cohorts, which were observed for five years. Of 3075 left hand-forearm radiographs of 426 children, a standard area of 10 x 10 mm of the radius was digitized and the trabecular pattern was described by ten image features. It is demonstrated that all image features show significant changes during the observation period (multivariate analysis of variance of p < 0.01). The age of the children correlates significantly with the image features (Spearman's Rho = 0.4; p < 0.05). Because of cohort effects, the three cohorts were studied separately. Highest correlations between age and trabecular pattern were shown in the cohort of the youngest children. The changes of the image features during the observation period seems to indicate that the fine trabecular pattern of young children changes into a coarser adult pattern. It is concluded that digital quantification of the radiographic trabecular pattern is appropriate to describe changes in trabecular bone.
ISSN:8756-3282
1873-2763
DOI:10.1016/8756-3282(95)00403-3