Protection against Naegleria fowleri infection in mice immunized with Cry1Ac plus amoebic lysates is dependent on the STAT6 Th2 response

We previously reported that intranasal administration of Cry1Ac protoxin alone or in combination with amoebic lysates increases protection against Naegleria fowleri meningoencephalitis in mice. Those results suggested that both antibody responses and innate immune mechanisms may be participating in...

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Bibliographic Details
Published in:	Parasite immunology 2010-09, Vol.32 (9-10), p.664-670
Main Authors:	CARRASCO-YEPEZ, M, ROJAS-HERNANDEZ, S, RODRIGUEZ-MONROY, M.A, TERRAZAS, L.I, MORENO-FIERROS, L
Format:	Article
Language:	English
Subjects:	Adjuvants, Immunologic Adjuvants, Immunologic - administration & dosage administration & dosage Administration, Intranasal Animals Bacterial Proteins Bacterial Proteins - administration & dosage Central Nervous System Protozoal Infections Central Nervous System Protozoal Infections - prevention & control Cry1Ac Drug Evaluation, Preclinical Endotoxins Endotoxins - administration & dosage Hemolysin Proteins Hemolysin Proteins - administration & dosage Immunization immunology intranasal immunization Male Mice Mice, Inbred BALB C Mice, Knockout Naegleria fowleri Naegleria fowleri - immunology prevention & control Protozoan Vaccines Protozoan Vaccines - administration & dosage Recombinant Proteins Recombinant Proteins - administration & dosage STAT6 STAT6 Transcription Factor STAT6 Transcription Factor - immunology Th2 Th2 Cells Th2 Cells - immunology
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