Initial Low-Dose Gentamicin for Staphylococcus aureus Bacteremia and Endocarditis Is Nephrotoxic

Background.The safety of adding initial low-dose gentamicin to antistaphylococcal penicillins or vancomycin for treatment of suspected Staphylococcus aureus native valve endocarditis is unknown. This study evaluated the association between this practice and nephrotoxicity. Methods.We performed a pro...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2009-03, Vol.48 (6), p.713-721
Main Authors: Cosgrove, Sara E., Vigliani, Gloria A., Campion, Marilyn, Fowler, Vance G., Abrutyn, Elias, Corey, G. Ralph, Levine, Donald P., Rupp, Mark E., Chambers, Henry F., Karchmer, Adolf W., Boucher, Helen W.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Articles and Commentaries
Bacteremia
Bacteremia - drug therapy
Bacteria
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Cardiology. Vascular system
Clinical trials
Cohort Studies
Creatinine - blood
Cubism
Daptomycin - therapeutic use
Dosage
Drug dosages
Drug therapy
Drug Therapy, Combination
Endocardial and cardiac valvular diseases
Endocarditis
Endocarditis, Bacterial - drug therapy
Female
Gentamicins - administration & dosage
Gentamicins - adverse effects
Gentamicins - therapeutic use
Heart
Human bacterial diseases
Humans
Infectious diseases
Kidney - drug effects
Male
Medical sciences
Medications
Metabolic Clearance Rate
Middle Aged
Nephrotoxicity
Penicillin
Penicillins - therapeutic use
Prospective Studies
Renal clearance
Safety
Staphylococcal Infections - drug therapy
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - isolation & purification
Studies
Vancomycin - therapeutic use
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background.The safety of adding initial low-dose gentamicin to antistaphylococcal penicillins or vancomycin for treatment of suspected Staphylococcus aureus native valve endocarditis is unknown. This study evaluated the association between this practice and nephrotoxicity. Methods.We performed a prospective cohort study of safety data from a randomized, controlled trial of therapy for S. aureus bacteremia and native valve infective endocarditis involving 236 patients from 44 hospitals in 4 countries. Patients either received standard therapy (antistaphylococcal penicillin or vancomycin) plus initial low-dose gentamicin (n=116) or received daptomycin monotherapy (n=120). We measured renal adverse events and clinically significant decreased creatinine clearance in patients (1) in the original randomized study arms and (2) who received any initial low-dose gentamicin either, as a study medication or
ISSN:1058-4838
1537-6591
DOI:10.1086/597031