Longitudinal 2 years field study of conventional vaccination against highly pathogenic avian influenza H5N1 in layer hens

Abstract A licensed, inactivated vaccine based on a low pathogenic avian influenza virus strain (H5N2) was evaluated in layer hens kept under field conditions during a 2-year period. Vaccine efficacy was investigated by specific antibodies and by challenge-contact experiments using highly pathogenic...

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Bibliographic Details
Published in:Vaccine 2010-10, Vol.28 (42), p.6832-6840
Main Authors: Rudolf, Miriam, Pöppel, Manfred, Fröhlich, Andreas, Breithaupt, Angele, Teifke, Jens, Blohm, Ulrike, Mettenleiter, Thomas, Beer, Martin, Harder, Timm
Format: Article
Language:English
Subjects:
Age
Allergy and Immunology
Animals
Antibodies, Viral - blood
Applied microbiology
Avian influenza
Biological and medical sciences
Birds
Cell Line
Chickens - immunology
Eggs
Female
Fundamental and applied biological sciences. Psychology
Hemagglutination Inhibition Tests
Immunization
Influenza A Virus, H5N1 Subtype - immunology
Influenza in Birds - immunology
Influenza in Birds - prevention & control
Influenza in Birds - transmission
Influenza Vaccines - immunology
Layer hens
Lethal Dose 50
Longitudinal field vaccination study
Longitudinal Studies
Microbiology
Miscellaneous
Poultry
RNA, Viral - isolation & purification
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - immunology
Virology
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Summary:Abstract A licensed, inactivated vaccine based on a low pathogenic avian influenza virus strain (H5N2) was evaluated in layer hens kept under field conditions during a 2-year period. Vaccine efficacy was investigated by specific antibodies and by challenge-contact experiments using highly pathogenic avian influenza viruses (HPAIV) H5N1. Basic immunization with two applications induced clinical protection. Virus excretion by vaccinated hens was significantly reduced compared to non-vaccinated controls; transmission to non-vaccinated and vaccinated contact birds was not fully interrupted. Vaccination efficacy is influenced by several factors including antigenic relatedness between vaccine and field strains, but also by species, age and type of commercial uses of the host. Limitations and risks of HPAIV vaccination as silent spread of HPAIV and emergence of escape mutants must be considered a priori and appropriate corrective measures have to be installed.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2010.08.038