Severe hyperkalaemia resulting from octreotide use in a haemodialysis patient

A 48-year-old man, with end-stage renal disease (ESRD) on haemodialysis, presented to the emergency department with sulphonylurea-induced hypoglycaemia. His hypoglycaemia was persistent despite glucose infusion, so he was treated with octreotide. Octreotide administration reversed the hypoglycaemia...

Full description

Saved in:
Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2010-10, Vol.25 (10), p.3439-3442
Main Authors: Adabala, Madhuri, Jhaveri, Kenar D., Gitman, Michael
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Emergency and intensive care: renal failure. Dialysis management
haemodialysis
Humans
hyperkalaemia
Hyperkalemia - chemically induced
Hypoglycemia - chemically induced
Hypoglycemia - drug therapy
Insulin - metabolism
Insulin Secretion
Intensive care medicine
Kidney Failure, Chronic - therapy
Male
Medical sciences
Middle Aged
octreotide
Octreotide - adverse effects
Octreotide - analogs & derivatives
Pharmacology. Drug treatments
Renal Dialysis
Sulfonylurea Compounds - antagonists & inhibitors
sulphonylurea agents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 48-year-old man, with end-stage renal disease (ESRD) on haemodialysis, presented to the emergency department with sulphonylurea-induced hypoglycaemia. His hypoglycaemia was persistent despite glucose infusion, so he was treated with octreotide. Octreotide administration reversed the hypoglycaemia but also resulted in severe hyperkalaemia. The patient was urgently dialysed, the octreotide was discontinued and his potassium normalized. We believe that the hyperkalaemia was caused by octreotide-induced insulin suppression and resultant impaired cellular potassium uptake. Although octreotide may be an effective therapy in refractory sulphonylurea-induced hypoglycaemia, it should be used with caution in patients on dialysis.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfq381