Lessons from regadenoson and low-level treadmill/regadenoson myocardial perfusion imaging: Initial clinical experience in 1263 patients

Background Regadenoson is a pharmacologic stress agent, which was recently approved for stress myocardial perfusion imaging (MPI). Aside from the initial protocol-driven studies, clinical experience with this stress agent is limited. Furthermore, low-level treadmill testing in a large population wit...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2010-10, Vol.17 (5), p.853-857
Main Authors: Kwon, Deborah H., Cerqueira, Manuel D., Young, Ron, Houghtaling, Penny, Lieber, Elizabeth, Menon, Venu, Brunken, Richard C., Jaber, Wael A.
Format: Article
Language:English
Subjects:
Adult
Aged
Cardiology
Exercise Test - methods
Female
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Perfusion Imaging - methods
Nuclear Medicine
Original Article
Purines
Pyrazoles
Radiology
Receptor, Adenosine A2A - physiology
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Background Regadenoson is a pharmacologic stress agent, which was recently approved for stress myocardial perfusion imaging (MPI). Aside from the initial protocol-driven studies, clinical experience with this stress agent is limited. Furthermore, low-level treadmill testing in a large population with regadenoson has not previously been evaluated. We describe our experience in the first 6 months of routine inpatient and outpatient clinical use. Methods Between 7/1/08 and 12/04/08, 1263 patients underwent regadenoson stress testing (596 with low-level treadmill, 667 supine). Past medical history, clinical symptoms during stress, and changes in systolic blood pressure were prospectively recorded. Results Low-level treadmill testing was well tolerated in our patient population. Shortness of breath, dizziness, palpitations, transient heart block, and nausea were less frequent when patients were able to exercise. In our population, 51% experienced a drop in systolic blood pressure greater than 10 mmHg, with 9% experiencing a decrease in more than 30 mmHg. This decrease in blood pressure was more common in patients who underwent low-level treadmill testing vs those that were supine (56% vs 47%, P -value 
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-010-9229-z