Modification of Radiation Sensitivity of Cultured Cells by Pre- and Postirradiation Incubation with Dibutyryl Cyclic AMP

The survival of exponentially growing JTC-11 cells, derived from ascites tumor cells, was enhanced when these cells were continuously treated with dibutyryl cyclic AMP for at least 6 hr before and 3 hr after X irradiation. While the$D_{{\rm q}}$did not change, the D0increased compared to that of the...

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Bibliographic Details
Published in:Radiation research 1981-01, Vol.85 (1), p.207-214
Main Authors: Kimura, Hiroshi, Yasui, Toshiko, Aoyama, Takashi
Format: Article
Language:English
Subjects:
Animals
Bucladesine - pharmacology
Cell growth
Cell lines
Cell Survival - drug effects
Cell Survival - radiation effects
Cells, Cultured
CHO cells
Correspondence
Cultured cells
DNA Repair - drug effects
Dosage
HeLa cells
Irradiation
L cells
L Cells (Cell Line)
Mice
Mitotic Index
Neoplasms, Experimental
Radiation damage
Radiation Tolerance
Space life sciences
Stem cells
Time Factors
X-Rays
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Summary:The survival of exponentially growing JTC-11 cells, derived from ascites tumor cells, was enhanced when these cells were continuously treated with dibutyryl cyclic AMP for at least 6 hr before and 3 hr after X irradiation. While the$D_{{\rm q}}$did not change, the D0increased compared to that of the irradiated JTC-11 cells not given dibutyryl cyclic AMP treatment or given only preirradiation treatment. Because of the increased D0value, the enhanced survival is probably a form of repair of potentially lethal radiation damage (PLDR), and the postirradiation treatment is important for this recovery. The recovery was not seen in mouse L cells. Since the manner of growth inhibition by dibutyryl cyclic AMP differed between JTC-11 cells and mouse L cells, the induction of the recovery from potentially lethal damage seen with application of the drug may involve a repair mechanism related to growth inhibition.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575451